S
S. West
Publications - 1
Citations - 347
S. West is an academic researcher. The author has contributed to research in topics: Receptor & Sphingosine-1-phosphate receptor. The author has an hindex of 1, co-authored 1 publications receiving 329 citations.
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Immune Cell Regulation and Cardiovascular Effects of Sphingosine 1-Phosphate Receptor Agonists in Rodents Are Mediated via Distinct Receptor Subtypes
Michael J. Forrest,S.-Y. Sun,Richard Hajdu,James D. Bergstrom,Deborah Card,George A. Doherty,Jeffrey J. Hale,Carol Ann Keohane,C. Meyers,James A. Milligan,Sander G. Mills,N. Nomura,Hugh Rosen,Mark Rosenbach,G.-J. Shei,I. I. Singer,M. Tian,S. West,V. White,Jenny Xie,Richard L. Proia,Suzanne M. Mandala +21 more
TL;DR: Three lines of evidence link S1P3 receptor activity with acute toxicity and cardiovascular regulation: compound potency on S 1P3 correlated with toxicity and bradycardia; the shift in potency of phosphorylated-FTY720 for inducing lymphopenia versus brady Cardia and hypertension was consistent with affinity for S1 p1 relative to S1p3; and toxicity, brady cardia, and hypertension were absent in S1 P3-/- mice.