S
Safiye Osman
Researcher at Hammersmith Hospital
Publications - 82
Citations - 5031
Safiye Osman is an academic researcher from Hammersmith Hospital. The author has contributed to research in topics: Radioligand & In vivo. The author has an hindex of 40, co-authored 82 publications receiving 4914 citations. Previous affiliations of Safiye Osman include GE Healthcare & Imperial College London.
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Journal ArticleDOI
Comparison of Methods for Analysis of Clinical [11C]Raclopride Studies
Adriaan A. Lammertsma,Christopher J. Bench,S.P. Hume,Safiye Osman,K. Gunn,David J. Brooks,R. S. J. Frackowiak +6 more
TL;DR: The reference tissue model provided estimates of the binding potential with the same sensitivity for detecting changes as those methods that required a metabolite-corrected plasma input function, indicating that for routine analysis of clinical [11C]raclopride studies, no arterial cannulation is required.
Journal Article
3'-deoxy-3'-[18F]fluorothymidine as a new marker for monitoring tumor response to antiproliferative therapy in vivo with positron emission tomography.
Henryk Barthel,Marcel C. Cleij,David R. Collingridge,O. Clyde Hutchinson,Safiye Osman,Qimin He,Sajinder K. Luthra,Frank Brady,Patricia M Price,Eric O. Aboagye +9 more
TL;DR: The ability to measure tumor response to antiproliferative treatment with [(18)F]FLT and PET and other than phosphorylation in tumors, [(18]F] FLT was found to be metabolically stable in vivo.
Journal ArticleDOI
Phase I Trial of the Positron-Emitting Arg-Gly-Asp (RGD) Peptide Radioligand 18F-AH111585 in Breast Cancer Patients
Laura M. Kenny,R. Charles Coombes,Inger Oulie,Kaiyumars B. Contractor,Matthew P. Miller,Terence J. Spinks,Brian McParland,Pamela S. Cohen,Ai-Min Hui,Carlo Palmieri,Safiye Osman,Matthias Glaser,David R. Turton,Adil Al-Nahhas,Eric O. Aboagye +14 more
TL;DR: 18F-AH111585 designed to bind the αvβ3 integrin is safe, metabolically stable, and retained in tumor tissues and detects breast cancer lesions by PET in most anatomic sites.
Journal ArticleDOI
Tracer Kinetic Modeling of the 5-HT1AReceptor Ligand [carbonyl-11C]WAY-100635 for PET
Roger N. Gunn,Peter A. Sargent,Christopher J. Bench,Eugenii A. Rabiner,Safiye Osman,Victor W. Pike,Susan P. Hume,Paul M. Grasby,Adriaan A. Lammertsma +8 more
TL;DR: It is concluded that a simplified reference tissue approach may be used to quantify 5-HT1A binding either in terms of ROI data or as parametric images.
Journal ArticleDOI
Exquisite delineation of 5-HT1A receptors in human brain with PET and [carbonyl-11C]WAY-100635
Victor W. Pike,Julie A. McCarron,Adriaan A. Lammertsma,Safiye Osman,Susan P. Hume,Peter A. Sargent,Christopher J. Bench,Ian Anthony Cliffe,Alan Fletcher,Paul M. Grasby +9 more
TL;DR: The acquired data provide exquisite delineation of 5-HT1A receptors in brain, with the ratio of radioactivity uptake in receptor-rich regions, such as medial temporal cortex, to that in receptors-devoid cerebellum reaching 25 by 60 min after radioligand injection.