Showing papers by "Sai Kiang Lim published in 2003"
TL;DR: It is shown that male mice had lower hepatic PON-1 mRNA that increased by 170% after castration and the data suggested that this effect was testes but not plasma testosterone dependent, and antioxidant Pon-1 is regulated at the mRNA level in a gender-specific manner by proinflammatory LPS and anti-inflammatory dexamethasone.
93 citations
TL;DR: Results show that in addition to its well-known effect of inhibition of PLA2 activity, quinacrine could also inhibit cPLA2 expression, and further supports a role for PLA2 in kainate-induced neuronal injury.
Abstract: The present investigation was carried out to study the possible effects of quinacrine in modulating cytoplasmic phospholipase A2 (cPLA2) mRNA levels in rat hippocampus after kainate treatment. Injections of kainate into the right lateral ventricle resulted in significant increases in cPLA2 mRNA levels in the hippocampus, at 3 days and 7 days after injection. The elevation in cPLA2 mRNA levels is consistent with previous observations of increased cPLA2 immunoreactivity in degenerating neurons and astrocytes at these times. Rats that received once daily intraperitoneal injections of quinacrine (5 mg/kg) after the intracerebroventricular kainate injections showed almost complete attenuation of increased cPLA2 expression, at both 3 and 7 days after kainate injection. These results show that in addition to its well-known effect of inhibition of PLA2 activity, quinacrine could also inhibit cPLA2 expression, and further supports a role for PLA2 in kainate-induced neuronal injury.
24 citations
TL;DR: It is shown that hepatic expression of Peroxisome proliferator‐activated receptor α (PPARα), a nuclear receptor that regulates lipid metabolism and inflammation, is regulated in a gender‐specific manner during lipopolysaccharide‐induced systemic inflammation.
23 citations
01 Jan 2003
TL;DR: It is shown that expression of Peroxisome proliferator-activated receptor K K (PPARK), a nuclear receptor that regulates lipid metabolism and in-ammation, is regulated in a gender-speci¢c manner dur- ing lipopolysaccharide (LPS)-induced systemic in£ammation.
Abstract: Dyslipidemia, in£ammation and gender are major risk factors in cardiovascular disease. Here we show that hepat- ic expression of Peroxisome proliferator-activated receptor K K (PPARK), a nuclear receptor that regulates lipid metabolism and in£ammation, is regulated in a gender-speci¢c manner dur- ing lipopolysaccharide (LPS)-induced systemic in£ammation. Immediately following LPS-induced systemic in£ammation, he- patic PPARK mRNA level decreased dramatically in mice. It was restored to baseline within 24 h in females but remained below baseline for s 72 h in male mice. In gonadectomized mice of both sexes, PPARK mRNA level was restored to baseline within 48 h after the initial decrease. . 2003 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.