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Samantha J. Steele
Researcher at AstraZeneca
Publications - 3
Citations - 658
Samantha J. Steele is an academic researcher from AstraZeneca. The author has contributed to research in topics: Transforming growth factor & Akt/PKB signaling pathway. The author has an hindex of 3, co-authored 3 publications receiving 607 citations.
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AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclinical models
Barry R. Davies,Armelle Logie,Jennifer S. McKay,Paul D. Martin,Samantha J. Steele,Richard O. Jenkins,Mark Cockerill,Sue Cartlidge,Paul D. Smith +8 more
TL;DR: In this paper, the potential of AZD6244 in combination with cytotoxic drugs was evaluated in mice bearing SW-620 xenografts, and the results indicated that enhanced antitumor efficacy can be obtained by combining AZD-6244 with either irinotecan or docetaxel.
Journal ArticleDOI
Induction of heart valve lesions by small-molecule ALK5 inhibitors.
Mark J. Anderton,Howard R. Mellor,Alex Bell,Claire Sadler,Martin Pass,Steve Powell,Samantha J. Steele,Ruth A. Roberts,Annabelle Heier +8 more
TL;DR: Findings suggest that TGF-β signaling via ALK5 plays a critical role in maintaining heart valve integrity.
Journal ArticleDOI
An antibody panel for immunohistochemical analysis of the retina in Davidson's-fixed, paraffin-embedded eyes of rats.
TL;DR: The methods outlined provide a platform for future detailed analysis of retinal pathology in Davidson's-fixed eyes by comparing a panel of six antibodies raised against rhodopsin, synaptophysin, glutamine synthetase, glial fibrillary acidic protein and cleaved caspase-3.