Chem. Pharm. Bull.(オピニオン)

Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Many chalcone derivatives have also been prepared due to their convenient synthesis. These natural products and synthetic compounds have shown numerous interesting biological activities with clinical potentials against various diseases. This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry. Multiple aspects of chalcone will be summarized herein, including the isolation of novel chalcone derivatives, the development of new synthetic methodologies, the evaluation of their biological properties, and the exploration of the mechanisms of action as well as target identification. This review is expected to be a comprehensive, authoritative, and critical review of the chalcone template to the chemistry community.

/pdf/chalcone-a-privileged-structure-in-medicinal-chemistry-2glhtivnj7.pdf

Chalcone: A Privileged Structure in Medicinal Chemistry.

https://www.cell.com/trends/biotechnology/pdf/S0167-7799(13)00015-2.pdf

The greener synthesis of nanoparticles

Silver nanoparticles: synthesis, properties, and therapeutic applications.

Zinc oxide nanoparticles: a promising nanomaterial for biomedical applications.

Nanomaterials in combating cancer: therapeutic applications and developments.

PEGylated silver doped zinc oxide nanoparticles as novel photosensitizers for photodynamic therapy against Leishmania

Fisheries and Aquaculture Laboratory, Department of Animal Sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan

https://journals.tubitak.gov.tr/zoology/issues/zoo-16-40-5/zoo-40-5-7-1510-5.pdf

Effects of dietary selenium nanoparticles on physiological andbiochemical aspects of juvenile Tor putitora

/pdf/zinc-oxide-zinc-sulfate-and-zinc-oxide-nanoparticles-as-3xy4q17egq.pdf

Zinc oxide, zinc sulfate and zinc oxide nanoparticles as source of dietary zinc: comparative effects on growth and hematological indices of juvenile grass carp (Ctenopharyngodon idella).

A 120-membered chalcone library has been designed and prepared from six differently substituted acetophenones (A 1 -A 6 ) and 20 benzaldehydes (B 1 -B 2 0 ). The library was subjected to biological studies targeted against six bacterial strains, tor the identification of the most-active member(s) of the library, the so-called indexed or positional -scanning method was applied. Six out of 26 sub-libraries, i.e.. ΛL 1 - - ΛL o were synthesized by keeping the acetophenone moiety A fixed and using equimolar quantities of the 20 different benzaldehydes. The remaining 20 sub-libraries BL 1 BL 2 0 were prepared by keeping the benzaldehyde B component fixed and varying the six acetoplienones (Table 1). The bactericidal activities of the resulting sub-libraries were tested and used as indices to the rows or columns of a two-dimensional matrix. Finally, parallel synthesis of 24 specific members with the highest-expected antibacterial activities, present in two sub-libraries, was carried out. These chalcones were screened again, and the results were exploited for establishing the structure-activity relationship (SAR) and the identification of the lead compound, which turned out to be 1,3-bis(2-hydroxyphenyl)prop-2-en-1-one (A 2 B 2 ) in terms of activity towards Staphylococcus aureus and Bacillus ubtilis (Tables 5-7).

Samina Nazir

Papers

Nanomaterials in combating cancer: therapeutic applications and developments.

PEGylated silver doped zinc oxide nanoparticles as novel photosensitizers for photodynamic therapy against Leishmania

Effects of dietary selenium nanoparticles on physiological andbiochemical aspects of juvenile Tor putitora

Zinc oxide, zinc sulfate and zinc oxide nanoparticles as source of dietary zinc: comparative effects on growth and hematological indices of juvenile grass carp (Ctenopharyngodon idella).

Combinatorial synthesis and antibacterial evaluation of an indexed chalcone library.