Sandro Sulfaro

TL;DR: Sentinel node biopsy is a reliable and reproducible means of staging the clinically N0 neck for patients with cT1/T2 HNSCC, and can be used as the sole staging tool for the majority of these patients, but cannot currently be recommended for Patients with tumors in the floor of the mouth.

TL;DR: SNB can be successfully applied to early T1/2 tumors of the oral cavity/oropharynx in a standardized fashion by centers worldwide and can be used alone as a staging tool.

TL;DR: The results suggest that at least three oncosuppressor genes mapping on 3p may be involved in head and neck cancer development and support a common oncogenic pathway with squamous cell lung cancer, for which a similar pattern of 3p deletion has been described recently.

TL;DR: The expression of CDC25A, CDC25B, and CDC25C genes in 20 squamous cell carcinomas of the head and neck are analyzed by quantitative reverse transcription-PCR on the basis of the evidence that CDC25 phosphatases can act as oncogenes.

TL;DR: The data suggest the existence of two new tumor suppressor genes (one close to and one distal to RB), which play a role in the development and/or progression of head and neck squamous cell carcinomas.