Sanket N. Dahotre

TL;DR: In this paper, a multiphysics computational model was developed to predict the nitrogen diffusion length into the Ti-6Al-4V alloy under various laser processing conditions (laser power and scanning speed).

TL;DR: Microstructural and phase observations, electrochemical analyses, corrosive wear evaluation, and cell behavior analysis of laser nitrided surface of bioimplant material (Ti–6Al–4V) indicated that laser nitRiding greatly improves the performance of bioIMplant material.

TL;DR: A novel integrated experimental and theoretical approach were implemented to understand the physical phenomena behind the improvements and establish the property-structure-processing correlation of nitrided surface and it is concluded that the enhancement in the corrosion resistance after laser nitriding is mainly attributed to the presence of covalent bonding via hybridization among Ti (p) and N (d) orbitals.

TL;DR: The aldehyde derivative of free fatty acid esters is identified as a byproduct of polysorbate oxidation that can be derivatized using 2,4‐dinitrophenylhydrazine and tracked analytically to monitor oxidative polys orbate degradation in pharmaceutical formulations.

TL;DR: In this paper , the authors present a fully automated and highly flexible method for direct monitoring of quality attributes (QAs) from the bioreactor, combining an automated sampling system and multi-dimensional (mD) LC-MS/MS technology to provide a means of quantifying posttranslational modifications (PTMs) during the cell culture process and making real-time process decisions based on the resulting peptide mapping data.