S
Sanseray da Silveira Cruz-Machado
Researcher at University of São Paulo
Publications - 22
Citations - 752
Sanseray da Silveira Cruz-Machado is an academic researcher from University of São Paulo. The author has contributed to research in topics: Melatonin & Pineal gland. The author has an hindex of 12, co-authored 21 publications receiving 604 citations. Previous affiliations of Sanseray da Silveira Cruz-Machado include University of Michigan.
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Journal ArticleDOI
Immune-pineal axis - acute inflammatory responses coordinate melatonin synthesis by pinealocytes and phagocytes.
Regina P. Markus,Pedro Fernandes,Gabriela Sarti Kinker,Sanseray da Silveira Cruz-Machado,Marina Marçola +4 more
TL;DR: The potential pathophysiological relevance of immune‐pineal axis dysregulation is highlighted, with both research and clinical implications, across several medical conditions, including host/parasite interaction, neurodegenerative diseases and cancer.
Journal ArticleDOI
TLR4 and CD14 receptors expressed in rat pineal gland trigger NFKB pathway.
Sanseray da Silveira Cruz-Machado,Claudia Emanuele Carvalho-Sousa,Eduardo Koji Tamura,Luciana Pinato,Luciana Pinato,Erika Cecon,Pedro Fernandes,Maria Christina W. Avellar,Maria Christina W. Avellar,Zulma S. Ferreira,Regina P. Markus +10 more
TL;DR: In this paper, the pineal glands possess both CD14 and toll-like receptor 4 (TLR4), membrane proteins that bind lipopolysaccharide (LPS) and trigger the NFKB pathway.
Journal ArticleDOI
Glia-Pinealocyte Network: The Paracrine Modulation of Melatonin Synthesis by Tumor Necrosis Factor (TNF)
Sanseray da Silveira Cruz-Machado,Luciana Pinato,Eduardo Koji Tamura,Claudia Emanuele Carvalho-Sousa,Regina P. Markus +4 more
TL;DR: The present study demonstrates the molecular and cellular basis for understanding how melatonin synthesis is regulated during an innate immune response, thus the role of the pineal gland as sensor of immune status is reinforced.
Journal ArticleDOI
Selective protection of the cerebellum against intracerebroventricular LPS is mediated by local melatonin synthesis.
Luciana Pinato,Luciana Pinato,Sanseray da Silveira Cruz-Machado,Daiane Gil Franco,Leila Maria Guissoni Campos,Erika Cecon,Pedro Fernandes,Jackson C. Bittencourt,Regina P. Markus +8 more
TL;DR: It is shown that acute neuroinflammation induced by lipopolysaccharide injected directly into the lateral ventricles of adult rats reduces the nocturnal peak of melatonin in the plasma and induces its synthesis in the cerebellum, though not in the cortex or hippocampus.
Journal ArticleDOI
Long-Lasting Priming of Endothelial Cells by Plasma Melatonin Levels
Eduardo Koji Tamura,Pedro Fernandes,Marina Marçola,Sanseray da Silveira Cruz-Machado,Regina P. Markus +4 more
TL;DR: The data strongly suggest that the plasma melatonin level primes endothelial cells “in vivo,” indicating that the state of the donor animal is translated to cells in culture and therefore, should be considered for establishing cell banks in ideal conditions.