Explanation in artificial intelligence: Insights from the social sciences

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic, which has resulted in global healthcare crises and strained health resources. As the population of patients recovering from COVID-19 grows, it is paramount to establish an understanding of the healthcare issues surrounding them. COVID-19 is now recognized as a multi-organ disease with a broad spectrum of manifestations. Similarly to post-acute viral syndromes described in survivors of other virulent coronavirus epidemics, there are increasing reports of persistent and prolonged effects after acute COVID-19. Patient advocacy groups, many members of which identify themselves as long haulers, have helped contribute to the recognition of post-acute COVID-19, a syndrome characterized by persistent symptoms and/or delayed or long-term complications beyond 4 weeks from the onset of symptoms. Here, we provide a comprehensive review of the current literature on post-acute COVID-19, its pathophysiology and its organ-specific sequelae. Finally, we discuss relevant considerations for the multidisciplinary care of COVID-19 survivors and propose a framework for the identification of those at high risk for post-acute COVID-19 and their coordinated management through dedicated COVID-19 clinics.

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Post-acute COVID-19 syndrome.

Our future: a Lancet commission on adolescent health and wellbeing

The self-medication hypothesis of addictive disorders derives primarily from clinical observations of patients with substance use disorders. Individuals discover that the specific actions or effects of each class of drugs relieve or change a range of painful affect states. Self-medication factors occur in a context of self-regulation vulnerabilities--primarily difficulties in regulating affects, self-esteem, relationships, and self-care. Persons with substance use disorders suffer in the extreme with their feelings, either being overwhelmed with painful affects or seeming not to feel their emotions at all. Substances of abuse help such individuals to relieve painful affects or to experience or control emotions when they are absent or confusing. Diagnostic studies provide evidence that variously supports and fails to support a self-medication hypothesis of addictive disorders. The cause-consequence controversy involving psychopathology and substance use/abuse is reviewed and critiqued. In contrast, clinical observations and empirical studies that focus on painful affects and subjective states of distress more consistently suggest that such states of suffering are important psychological determinants in using, becoming dependent upon, and relapsing to addictive substances. Subjective states of distress and suffering involved in motives to self-medicate with substances of abuse are considered with respect to nicotine dependence and to schizophrenia and posttraumatic stress disorder comorbid with a substance use disorder.

The Self-medication Hypothesis of Substance Use Disorders: A Reconsideration and Recent Applications

This meta-analysis explores the location and function of brain areas involved in social cognition, or the capacity to understand people's behavioral intentions, social beliefs, and personality traits. On the basis of over 200 fMRI studies, it tests alternative theoretical proposals that attempt to explain how several brain areas process information relevant for social cognition. The results suggest that inferring temporary states such as goals, intentions, and desires of other people-even when they are false and unjust from our own perspective--strongly engages the temporo-parietal junction (TPJ). Inferring more enduring dispositions of others and the self, or interpersonal norms and scripts, engages the medial prefrontal cortex (mPFC), although temporal states can also activate the mPFC. Other candidate tasks reflecting general-purpose brain processes that may potentially subserve social cognition are briefly reviewed, such as sequence learning, causality detection, emotion processing, and executive functioning (action monitoring, attention, dual task monitoring, episodic memory retrieval), but none of them overlaps uniquely with the regions activated during social cognition. Hence, it appears that social cognition particularly engages the TPJ and mPFC regions. The available evidence is consistent with the role of a TPJ-related mirror system for inferring temporary goals and intentions at a relatively perceptual level of representation, and the mPFC as a module that integrates social information across time and allows reflection and representation of traits and norms, and presumably also of intentionality, at a more abstract cognitive level.

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Social cognition and the brain: a meta-analysis.

Premature adolescent autonomy: parent disengagement and deviant peer process in the amplification of problem behaviour.

The family check-up with high-risk young adolescents: Preventing early-onset substance use by parent monitoring

The Adolescent Transitions Program (ATP) promotes student adjustment and reduces risk within a public school setting, focusing primarily on parenting practices using a tiered, multilevel prevention strategy A description is given of the program, levels of engagement, and intervention effects Within each school, multiethnic students (N = 672) and their families were randomly assigned at the individual level to a control condition or the ATP intervention Analyses focus on the longitudinal effects of the ATP intervention on self-reported substance use through middle school and the 1st year of high school (Grades 6, 7, 8, and 9) Levels of engagement in the selected and indicated interventions were somewhat less than expected Despite relatively low levels of engagement, the intervention reduced initiation of substance use in both at-risk and typically developing students These findings are discussed with respect to lessons learned about parent engagement, optimizing strategies for schoolwide implementation, and the promise of embedding family interventions within the public school ecology

Preventing Early Adolescent Substance Use: A Family-Centered Strategy for the Public Middle School

Traditional attribution theory conceptualizes explanations of behavior as referring to either dispositional or situational causes. An alternative approach, the folk-conceptual theory of behavior explanation, distinguishes multiple discrete modes of explanation and specific features within each mode. Because attribution theory and the folk-conceptual theory carve up behavior explanations in distinct ways, they offer very different predictions about actor-observer asymmetries. Six studies, varying in contexts and methodologies, pit the 2 sets of predictions against each other. There was no evidence for the traditional actor-observer hypothesis, but systematic support was found for the actor-observer asymmetries hypothesized by the folk-conceptual theory. The studies also provide initial evidence for the processes that drive each of the asymmetries: impression management goals, general knowledge, and copresence.

/pdf/actor-observer-asymmetries-in-explanations-of-behavior-new-1h44mh53d6.pdf

Actor-observer asymmetries in explanations of behavior: new answers to an old question.

A dynamic systems framework was applied to understand the influence of friendship on antisocial behavior from childhood (age 9–10) through adulthood (age 24–25) for Oregon Youth Study males (N = 206). Boys were videotaped interacting with a friend at ages 14, 16, and 18, and deviant content and interpersonal processes were independently coded. Conditional dyadic interpersonal processes were studied as a communication system and summarized by an index of information entropy (F. Attneave, 1959). High entropy scores represent disorganized, unpredictable patterns of interaction, whereas low entropy scores reflect an organized dialogue. Conversations of early-onset antisocial boys and their best friends were less organized and included more deviant content than those of well-adjusted controls. Prediction analyses, however, revealed an interaction between entropy and deviant talk. Consistent with expectation, males with well-organized interactions (i.e., low entropy) but elevated levels of deviant content were most likely to continue antisocial behavior into adulthood. Findings suggest that individual risk for maladaptation may be amplified by early adolescent friendship dynamics organized around deviance.

Sarah E. Nelson

Papers

Premature adolescent autonomy: parent disengagement and deviant peer process in the amplification of problem behaviour.

The family check-up with high-risk young adolescents: Preventing early-onset substance use by parent monitoring

Preventing Early Adolescent Substance Use: A Family-Centered Strategy for the Public Middle School

Actor-observer asymmetries in explanations of behavior: new answers to an old question.

Adolescent Friendship as a Dynamic System: Entropy and Deviance in the Etiology and Course of Male Antisocial Behavior.