S
Satoshi Horii
Researcher at Takeda Pharmaceutical Company
Publications - 65
Citations - 1714
Satoshi Horii is an academic researcher from Takeda Pharmaceutical Company. The author has contributed to research in topics: Validamycin & Valienamine. The author has an hindex of 22, co-authored 65 publications receiving 1685 citations.
Papers
More filters
Journal ArticleDOI
Synthesis and alpha-D-glucosidase inhibitory activity of N-substituted valiolamine derivatives as potential oral antidiabetic agents.
TL;DR: Various kinds of N-substituted valiolamine derivatives, including compounds 23a, 24a, and 34a, which are structurally analogous to the key pseudodisaccharides of naturally occurring oligosaccharide alpha-D-glucosidase inhibitors, have been synthesized and estimated by the measure of inhibitory activity against porcine sucrase and maltase.
Journal ArticleDOI
Valiolamine, a new alpha-glucosidase inhibiting aminocyclitol produced by Streptomyces hygroscopicus.
Yukihiko Kameda,Naoki Asano,Michiyo Yoshikawa,Masayoshi Takeuchi,Takuji Yamaguchi,Katsuhiko Matsui,Satoshi Horii,Hiroshi Fukase +7 more
TL;DR: Valiolamine has more potent alpha-glucosidase inhibitory activity against porcine intestinal sucrase, maltase and isomaltase than valienamine, validamine and hydroxyvalidamine which were reported as building blocks of validamycins and microbial oligosaccharide alpha- glucosIDase inhibitors.
Journal ArticleDOI
The unsaturated cyclitol part of the new antibiotics, the validamycins
Yukihiko Kameda,Satoshi Horii +1 more
TL;DR: The structure of epivalidamine, a new aminocyclitol derived from dihydrovalidamycin A was also elucidated, establishing the structure of the unsaturated cyclitol portion of valid Amycin A.
Journal ArticleDOI
Studies on validamycins, new antibiotics. VI. Validamine, hydroxyvalidamine and validatol, new cyclitols.
Journal ArticleDOI
Studies on validamycins, new antibiotics. 8. Isolation and characterization of validamycins C,D,E and F.
TL;DR: The isolation and characterization of four components of validamycin complex, validamycins C, D, E and F, in addition to valid Amycins A and B reported in the previous papers are described.