Showing papers by "Saul Suster published in 1986"

Sclerosing hemangioma of the lung: immunohistochemical demonstration of mesenchymal origin using antibodies to tissue-specific intermediate filaments

Abstract: A case of pulmonary sclerosing hemangioma of the lung was studied by light microscopy and indirect immunofluorescence using tissue-specific antibodies against intermediate filament subunits. All the tumor cells stained positively and exclusively with antivimentin antibodies thus indicating their mesenchymal origin. In addition, positive staining with cytokeratin antibodies was observed in cells lining cystic spaces and elongated slit-like spaces were occasionally encountered throughout the tumor, disclosing residual epithelial elements. Using brightfield microscopy, the keratin-positive areas were identified as distorted alveolar spaces lined by hyperplastic respiratory epithelium entrapped within the tumor. It is proposed that these entrapped epithelial elements may account for the conflicting results obtained by different investigators in previous attempts to determine the histogenesis of this tumor.

Familial atrophie blanche-like lesions with subcutaneous fibrinoid vasculitis. The Georgian ulcers.

Abstract: Atrophie blanche is an uncommon condition characterized by the development of white atrophic patches of skin on the lower extremities, which form as a result of fibrinoid vasculitis of superficial and mid-dermal vessels followed by necrosis and ulceration of the epidermis. We report four cases in which similar lesions developed on the legs and ankles of young Jewish Russian immigrants to Israel. Although the lesions share many features with atrophie blanche, they differ in their early age of onset, the male predilection, and the extension of the fibrinoid vasculitic process into the subcutaneous tissue. Additionally, the peculiar population clustering (Georgia, U.S.S.R.), common ethnic background, and a family history of similar lesions in close relatives seem to point to a familial or genetic predisposition underlying the development of the disease.

Bullous skin lesion in familial Mediterranean fever.

Abstract: An unusual painful bullous skin lesion of the foot occurred in a 49-year-old woman as the only clinical manifestation of familial Mediterranean fever. The lesion preceded other symptoms of the disease by several years and responded only to treatment with colchicine. Recognition of this peculiar skin lesion may lead to an earlier diagnosis of the disease.

Contact dermatitis due to karaya gum and induced by the application of electrodes.

Abstract: I case 1, a 15-year-old woman who suffered from progressive mild idiopathic scoliosis, was treated with transcutaneous electrical muscle stimulation. The electrical stimulus was applied during her sleep through surface contact with karaya electrode pads on the convex side of the curve of her spine, evoking muscle contractions that induced correction of the curvature (Fig. 1). Five days after the initiation of treatment, a red area of swelling accompanied by pruritis appeared at the site of the electrode placement (Fig. 2). Treatment was discontinued for 10 days and later reinstituted, obtaining the same effect. She was treated with 10 mg/day of prednisone for 5 days and then 5 mg/day for an additional 10 days. Due to her severe back pain, treatment with the electrode placement was attempted again, but the rapid deterioration in her skin condition made it necessary to discontinue treatment.

Transformation of Hodgkin's disease into malignant fibrous histiocytoma.

Abstract: The continuity that exists between Hodgkin's disease and the fibrohistiocytoses has only recently been recognized Four cases are presented that illustrate this phenomenon The fibrohistiocytic component of the Hodgkin's lesion may lag behind the lymphoreticular component, may be present in equal proportion, or may assume a dominant role, with the emergence of a frank fibrohistiocytosis or fibrous histiocytoma being evidenced as the lymphoreticular component recedes

Effects of Solcoderm

Abstract: The effects of treatment and depths of penetration of a 5-fluorouracil and salicylic acid preparation (Solcoderm) were studied in 24 patients treated for basal cell carcinoma with this compound. Two thirds of the patients in our study showed islands of residual tumor in the dermis following treatment, whereas total disappearance of the tumor was observed in one third. The depth of the fibrotic changes induced by the drug varied from 0.34 to 0.40 cm for the morphea type of basal cell carcinoma and from 0.52 to 0.88 cm for the conventional types. It is recommended that treatment with this compound be reserved only for superficial basal cell carcinomas and that it be avoided altogether in basal cell carcinomas of the morphea type.

Trabecular carcinoma of the skin simulating metastatic disease.

Abstract: A case of trabecular carcinoma of the skin that resulted in prequarter amputation of the arm for local tumor aggressiveness is presented. The tumor was originally diagnosed as metastatic, most probably neuroblastoma, leading to inadequate local resection that resulted in recurrence with extensive regional nodal metastases. The importance of recognizing trabecular carcinoma as a primary tumor of the skin with a potential for recurrence and metastasis is underscored, primarily since initial total excision with adequate margins of resection has proven in most instances to be curative.