Showing papers by "Saulnier Mark G published in 1995"
TL;DR: In this paper, a palladium(0)-catalyzed polyannulation reaction was proposed for the assembly of the parent Indolo[2,3-a] carbazole ring system, where 4 bonds are formed in a single step from a simple monocyclic 1,3diacetylene precursor.
77 citations
Patent•
25 Oct 1995
TL;DR: In this paper, a process for preparing 4'-demethylepipodophyllotoxin glucoside 4'-phosphate was described, which consisted in reacting a protected 4'-DEMethylpodophyllotsotoxin with a protected glucopyranose in the presence of a Lewis acid, followed by deprotection.
Abstract: The present invention relates to a process for preparing 4'-demethylepipodophyllotoxin glucoside 4'-phosphate, which comprise reacting a protected 4'-demethylpodophyllotoxin with a protected glucopyranose in the presence of a Lewis acid, followed by deprotection.
2 citations
TL;DR: In this paper, a new class of guanidino prodrug is efficiently synthesized from an amine and an appropriate N,N′-bis(acyloxymethoxycarbonyl)-S-methylisothiourea.
Abstract: A new class of guanidino prodrug is efficiently synthesized from an amine and an appropriate N,N′-bis(acyloxymethoxycarbonyl)-S-methylisothiourea. The N,N′-bis(acyloxymethoxycarbonyl)-S-methylisothiourea is readily prepared from S-methylisothiourea and the corresponding acyloxymethyl carbonochloridate in good yield. The N,N′-bis(acyloxymethyl carbamate) derivatives of the highly basic guanidino group serve as lipophilic, uncharged, esterase-activatable prodrugs of simple guanidine containing molecules.