I have developed "tennis elbow" from lugging this book around the past four weeks, but it is worth the pain, the effort, and the aspirin. It is also worth the (relatively speaking) bargain price. Including appendixes, this book contains 894 pages of text. The entire panorama of the neural sciences is surveyed and examined, and it is comprehensive in its scope, from genomes to social behaviors. The editors explicitly state that the book is designed as "an introductory text for students of biology, behavior, and medicine," but it is hard to imagine any audience, interested in any fragment of neuroscience at any level of sophistication, that would not enjoy this book. The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or

Principles of Neural Science

General Strategies.- Regression Models.- Classification Models.- Other Considerations.- Appendix.- References.- Indices.

Applied Predictive Modeling

The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

The Medicinal Chemist's Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

Theoretical Methods for the Description of the Solvent Effect in Biomolecular Systems.

Imidazole ring is an important five-membered aromatic heterocycle widely present in natural products and synthetic molecules. The unique structural feature of imidazole ring with desirable electron-rich characteristic is beneficial for imidazole derivatives to readily bind with a variety of enzymes and receptors in biological systems through diverse weak interactions, thereby exhibiting broad bioactivities. The related research and developments of imidazole-based medicinal chemistry have become a rapidly developing and increasingly active topic. Particularly, numerous imidazole-based compounds as clinical drugs have been extensively used in the clinic to treat various types of diseases with high therapeutic potency, which have shown the enormous development value. This work systematically gives a comprehensive review in current developments of imidazole-based compounds in the whole range of medicinal chemistry as anticancer, antifungal, antibacterial, antitubercular, anti-inflammatory, antineuropathic, antihypertensive, antihistaminic, antiparasitic, antiobesity, antiviral, and other medicinal agents, together with their potential applications in diagnostics and pathology. It is hoped that this review will be helpful for new thoughts in the quest for rational designs of more active and less toxic imidazole-based medicinal drugs, as well as more effective diagnostic agents and pathologic probes.

Comprehensive Review in Current Developments of Imidazole‐Based Medicinal Chemistry

La presente invention concerne, en partie, des composes representes par la formule (I) : (I) et leurs sels pharmaceutiquement acceptables ; des procedes pour leur preparation ; des intermediaires utilises dans leur preparation ; et des compositions contenant de tels composes ou sels et leurs utilisations pour le traitement de pathologies mediees par le D1 (ou associees au D1), notamment la schizophrenie (par ex., ses symptomes cognitifs et negatifs), le deficit cognitif (par ex., le deficit cognitif associe a la schizophrenie, la MA, la MP ou une pharmacotherapie), le declin des facultes mentales lie a l'âge, la demence et la maladie de Parkinson.

Scot Richard Mente

Papers

Composés hétéro-aromatiques et leur utilisation en tant que ligands d1 de la dopamine

Fused pyridine compounds as casein kinase inhibitors