S
Scott E. Walker
Researcher at Sunnybrook Health Sciences Centre
Publications - 153
Citations - 2959
Scott E. Walker is an academic researcher from Sunnybrook Health Sciences Centre. The author has contributed to research in topics: Pharmacokinetics & Febrile neutropenia. The author has an hindex of 27, co-authored 152 publications receiving 2721 citations. Previous affiliations of Scott E. Walker include Women's College, Kolkata & Women's College Hospital.
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Journal ArticleDOI
Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method.
Vural Özdemir,Werner Kalow,Bing Kou Tang,Andrew D. Paterson,Scott E. Walker,Laszlo Endrenyi,Angela D. M. Kashuba +6 more
TL;DR: The aim of the present analysis was to assess the genetic control of CYP3A4 activity in vivo and indicated that further molecular genetic investigations are warranted to identify genetic variants at CYP 3A4 or elsewhere in the genome which contribute to regulation of CYp3A 4 activity.
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Current Place of Monoamine Oxidase Inhibitors in the Treatment of Depression
TL;DR: The discovery and history of the use of irreversible monoamine oxidase (MAO) inhibitors such as phenelzine, tranylcypromine and isocarboxazid as well as the second generation selective and reversible MAOIs such as the MAO-A inhibitor, moclobemide and theMAO-B inhibitor, selegiline are reviewed.
Journal Article
Phase I Pharmacokinetic Study of Cyclosporin A Combined with Doxorubicin
Charles Erlichman,Malcolm J. Moore,Jake J. Thiessen,Ian G. Kerr,Scott E. Walker,Phyllis Goodman,Georg A. Bjarnason,Carlo DeAngelis,Peter S. Bunting +8 more
TL;DR: It is concluded that dox can be combined with infusioned CsA but at a lower dose than when given alone, and may be due to altered metabolism and/or excretion of dox or increased bone marrow stem cell sensitivity to dox.
Journal Article
The making of a user friendly MAOI diet.
TL;DR: This work proposes an MAOI diet that has a solid scientific and clinical basis and that is, above all, practical and recommends that users avoid aged cheese; aged or cured meats; and tap beer.
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Reporting Guidelines for Clinical Pharmacokinetic Studies: The ClinPK Statement
Salmaan Kanji,Meghan Hayes,Adam Ling,Larissa Shamseer,Larissa Shamseer,Clarence Chant,Clarence Chant,David J. Edwards,Scott Edwards,Mary H H Ensom,David R. Foster,Brian G. Hardy,Brian G. Hardy,Tyree H. Kiser,Charles la Porte,Jason A. Roberts,Jason A. Roberts,Jason A. Roberts,Rob Shulman,Scott E. Walker,Sheryl A. Zelenitsky,David Moher,David Moher +22 more
TL;DR: A tool to guide transparent and accurate reporting of clinical pharmacokinetic studies is developed using consensus methods to promote more consistent reporting of these studies and allow for better assessment of utility for clinical applications.