Scott J. Myers

TL;DR: This review discusses International Union of Basic and Clinical Pharmacology glutamate receptor nomenclature, structure, assembly, accessory subunits, interacting proteins, gene expression and translation, post-translational modifications, agonist and antagonist pharmacology, allosteric modulation, mechanisms of gating and permeation, roles in normal physiological function, as well as the potential therapeutic use of pharmacological agents acting at glutamate receptors.

TL;DR: This work provides multiple lines of evidence that the N-terminal domain of REST represses transcription of the GluR2 and type II sodium-channel genes by recruiting the corepressor Sin3A and histone deacetylase to the promoter region in nonneuronal cells.

TL;DR: Current reports of disease-associated variants in GRIN2B from patients with multiple neurodevelopmental disorders are summarized, and implications are discussed, highlighting the importance of functional analysis and precision medicine therapies.

TL;DR: In this paper, the authors cloned the 59 proximal region of the rat gene and investigated GluR2 promoter activity by transient transfection, finding that Glu-R2 transcription initiates from multiple sites, is highly neuronal selective, and is regulated by three regulatory elements in the proximal promoter region.

TL;DR: Manipulating the levels of glutamate receptors in vivo by generating transgenic and knockout mice has enhanced understanding of the role of specific glutamate receptor subunits in long-term potentiation and depression, learning, seizures, neural pattern formation, and survival.