S
Sean C. Goetsch
Researcher at University of Texas Southwestern Medical Center
Publications - 24
Citations - 2215
Sean C. Goetsch is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Progenitor cell & Myocyte. The author has an hindex of 17, co-authored 22 publications receiving 2022 citations.
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Journal ArticleDOI
Persistent expression of the ATP-binding cassette transporter, Abcg2, identifies cardiac SP cells in the developing and adult heart.
Cindy M. Martin,Annette Meeson,Scott M. Robertson,Thomas J. Hawke,James A. Richardson,Susan E. Bates,Sean C. Goetsch,Teresa D. Gallardo,Daniel J. Garry +8 more
TL;DR: The adult heart contains an Abcg2 expressing SP cell population and these progenitor cells are capable of proliferation and differentiation, and it is proposed that the cardiac SPcell population functions as a progenitors cell population for the development, maintenance, and repair of the heart.
Journal ArticleDOI
The bHLH transcription factor Tcf21 is required for lineage-specific EMT of cardiac fibroblast progenitors
Asha Acharya,Seung Tae Baek,Guo N. Huang,Banu Eskiocak,Sean C. Goetsch,Caroline Y. Sung,Serena Banfi,Marion F. Sauer,Gregory S. Olsen,Jeremy S. Duffield,Eric N. Olson,Michelle D. Tallquist +11 more
TL;DR: A unique role for Tcf21 is demonstrated in multipotent epicardial progenitors, prior to the process of EMT that is essential for cardiac fibroblast development, the first report of a transcription factor essential for the development of cardiac Fibroblasts.
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Transcriptional profiling and regulation of the extracellular matrix during muscle regeneration.
TL;DR: It is concluded that muscle regeneration is a complex process that requires the coordinated modulation of the inflammatory response, myogenic progenitor cells, growth factors, and ECM for complete restoration of muscle architecture.
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Neuroglobin, a novel member of the globin family, is expressed in focal regions of the brain.
Pradeep P.A. Mammen,John M. Shelton,Sean C. Goetsch,S. Clay Williams,James A. Richardson,Mary G. Garry,Daniel J. Garry +6 more
TL;DR: The hypothesis that neuroglobin is a hemoprotein that is expressed in the brain and may have diverse functional roles is supported.
Journal ArticleDOI
A Dynamic Notch Injury Response Activates Epicardium and Contributes to Fibrosis Repair
TL;DR: A dynamic Notch injury response activates adult epicardium, producing a multipotent cell population that contributes to fibrosis repair and increases cardiac gene expression in NECs.