S
Sean J. Pittock
Researcher at University of Rochester
Publications - 38
Citations - 2870
Sean J. Pittock is an academic researcher from University of Rochester. The author has contributed to research in topics: Neuromyelitis optica & Eculizumab. The author has an hindex of 12, co-authored 38 publications receiving 2618 citations.
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Journal ArticleDOI
Serologic diagnosis of NMO: A multicenter comparison of aquaporin-4-IgG assays
Patrick Waters,Andrew McKeon,Maria Isabel Leite,Sathyanath Rajasekharan,Vanda A. Lennon,Ada Villalobos,Jacqueline Palace,Jay Mandrekar,Angela Vincent,Amit Bar-Or,Sean J. Pittock +10 more
TL;DR: The greater sensitivity and excellent specificity of second-generation recombinant antigen-based assays for detection of NMO-IgG in a clinical setting should enable earlier diagnosis of N MO spectrum disorders and prompt initiation of disease-appropriate therapies.
Journal ArticleDOI
Pathogenic potential of IgG binding to water channel extracellular domain in neuromyelitis optica
Shannon R. Hinson,Sean J. Pittock,C. F. Lucchinetti,Shanu F. Roemer,J. P. Fryer,Thomas J. Kryzer,Vanda A. Lennon +6 more
TL;DR: NMO patients’ serum IgG has a selective pathologic effect on cell membranes expressing aquaporin-4, and targeting astrocytic processes around nodes of Ranvier could initiate demyelination.
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NMO-IgG predicts the outcome of recurrent optic neuritis
Marcelo Matiello,Vanda A. Lennon,Anu Jacob,Sean J. Pittock,Claudia F. Lucchinetti,Dean M. Wingerchuk,Brian G. Weinshenker +6 more
TL;DR: Neuromyelitis optica (NMO)–immunoglobulin G seropositivity predicts poor visual outcome and development of NMO and seropositive recurrent optic neuritis is a limited form of N MO.
Journal ArticleDOI
A secondary progressive clinical course is uncommon in neuromyelitis optica
Dean M. Wingerchuk,Sean J. Pittock,Claudia F. Lucchinetti,Vanda A. Lennon,Brian G. Weinshenker +4 more
TL;DR: The disparate natural histories of MS and NMO suggest dissociation between relapses and clinical progression in CNS demyelinating diseases.
Journal ArticleDOI
Neuromyelitis optica unique area postrema lesions: Nausea, vomiting, and pathogenic implications
B.F.Gh. Popescu,Vanda A. Lennon,Joseph E. Parisi,Charles L. Howe,Stephen D. Weigand,J.A. Cabrera-Gómez,Kathy L. Newell,Raul N. Mandler,Sean J. Pittock,Brian G. Weinshenker,Claudia F. Lucchinetti +10 more
TL;DR: These neuropathologic findings suggest the area postrema may be a selective target of the disease process in NMO, and are compatible with clinical reports of nausea and vomiting preceding episodes of optic neuritis and transverse myelitis or being the heralding symptom of NMO.