Sebastian Liber

TL;DR: It is concluded that orally-dosed metformin rapidly crosses the blood-brain barrier and differently accumulates in structures of the central nervous system.

TL;DR: It is believed that metformin-based therapy, a cornerstone in diabetes therapy, not only improves the prognosis of diabetics by reducing blood glucose but also by reducing oxidative stress, inflammatory cytokine production and the shift toward alternative activation of macrophages.

TL;DR: The presented evidence supports the conclusion that metformin-activated AMPK participates in regulating the release of TNF-α and proposes that the shift of microglia toward alternative activation may underlie the beneficial effects of met formin observed in animal models of neurological disorders.

TL;DR: It is shown that metformin increased AMPK activity in microglial cells and that all observed effects are AMPK-dependent because the pretreatment of microglia with compound C reversed the effects of the drug.

TL;DR: In this article, the authors investigated the contribution of AMPK activation to autophagy activation in rat primary astrocyte cultures subjected to ischemia-simulating conditions (combined oxygen glucose deprivation, OGD) and its potential effects on the damage induced by OGD.