S
Selcuk A. Tanik
Researcher at University of Pennsylvania
Publications - 3
Citations - 1508
Selcuk A. Tanik is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Autophagosome & HEK 293 cells. The author has an hindex of 2, co-authored 3 publications receiving 1245 citations.
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Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death.
Laura A. Volpicelli-Daley,Kelvin C. Luk,Tapan P. Patel,Selcuk A. Tanik,Dawn M. Riddle,Anna Stieber,David F. Meaney,John Q. Trojanowski,Virginia M.-Y. Lee +8 more
TL;DR: It is demonstrated that preformed fibrils generated from full-length and truncated recombinant α-syn enter primary neurons, probably by adsorptive-mediated endocytosis, and promote recruitment of soluble endogenousα-syn into insoluble PD-like LBs and LNs.
Journal ArticleDOI
Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy
Selcuk A. Tanik,Christine E. Schultheiss,Laura A. Volpicelli-Daley,Kurt R. Brunden,Virginia M.-Y. Lee +4 more
TL;DR: It is demonstrated that α-syn inclusions cannot be effectively degraded, even though they co-localize with essential components of both the autophagic and proteasomal protein degradation pathways.
well as regulated genes be identified? high store-operated calcium entry: can regulatory as Gene expression profiles in HEK-293 cells with low or
Tatiana K. Zagranichnaya,Xiaoyan Wu,Arpad M. Danos,Mitchel L. Villereal,Virginia M. Y. Lee,Selcuk A. Tanik,Christine E. Schultheiss,Laura A. Volpicelli-Daley,Kurt R. Brunden,Lewy Body-like,Raymond M.H. Wong,Lyanne C. Schlichter +11 more