Showing papers by "Senthamaraikannan Kabilan published in 2020"
TL;DR: In this paper, single crystals of (E)-N'-((1-,chloro-3,4-dihydronaphthalen-2-yl)methylene)-3-nitro benzohydrazide and(E)-3]-chloro n'-n'-(( 1-chloro, 3,4dihdronaphthyn-2,yl) methylene) benzhydrazide were grown from the (DMSO/CDCl3) by slow evaporation growth technique.
32 citations
TL;DR: In the title compound, C18H15ClN2O·H2O, the dihedral angle between the mean plane of the dihydronaphthalene ring system and the phenyl ring is 17.1 (2)°.
Abstract: In the title compound, C18H15ClN2O·H2O, a benzohydrazide derivative, the dihedral angle between the mean plane of the dihydronaphthalene ring system and the phenyl ring is 17.1 (2)°. In the crystal, O—H⋯O, N—H⋯O and C—H⋯O hydrogen bonds link the benzohydrazide and water molecules, forming a layer parallel to the bc plane. Hirshfeld surface analysis and two-dimensional fingerprint plots indicate that the most important contributions to the crystal packing are from H⋯H (45.7%) and H⋯C/C⋯H (20.2%) contacts.
24 citations
TL;DR: The compounds with the methoxy (in 4c) and methyl substitution were shown to have significant cytotoxicity, with 4c showing dose‐dependent activation and decreased cell viability, and the toxicity properties of ADME were calculated for all the compounds.
Abstract: Breast Cancer (BCa) is the most often diagnosed cancer among women who were in the late 1940's. Breast cancer growth is largely dependent on the expression of estrogen and progesterone receptor. Breast cancer cells may have one, both, or none of these receptors. The treatment for breast cancer may involve surgery, hormonal therapy (Tamoxifen, an aromatase inhibitor, etc.) and oral chemotherapeutic drugs. The molecular docking technique reported the findings on the potential binding modes of the 2-(2-bromo-3-nitrophenyl)-5-phenyl-1,3,4-oxadiazole derivatives with the estrogen receptor (PDB ID: 3ERT). The 1,3,4-oxadiazole derivatives 4a-4j have been synthesized and described by spectroscopic method. 2-(2-Bromo-6-nitrophenyl)-5-(4-bromophenyl)-1,3,4-oxadiazole (4c) was reconfirmed by single-crystal XRD. All the compounds have been tested in combination with generic Imatinib pharmaceutical drug against breast cancer cell lines isolated from Caucasian woman MCF-7, MDA-MB-453 and MCF-10A non-cancer cell lines. The compounds with the methoxy (in 4c) and methyl (in 4j) substitution were shown to have significant cytotoxicity, with 4c showing dose-dependent activation and decreased cell viability. The mechanism of action was reported by induced apoptosis and tested by a DNA enzyme inhibitor experiment (ELISA) for Methyl Transferase. Molecular dynamics simulations were made for hit molecule 4c to study the stability and interaction of the protein-ligand complex. The toxicity properties of ADME were calculated for all the compounds. All these results provide essential information for further clinical trials.
17 citations
TL;DR: The present investigation was intended to characterize pigments for the first time from Rhodotorula taiwanensis yeast isolated from the ethic fermentation starter culture source meant to evaluate its carotenoid contents for beneficial applications.
Abstract: The present investigation was intended to characterize pigments for the first time from Rhodotorula taiwanensis (LC011412) yeast isolated from the ethic fermentation starter culture source meant to evaluate its carotenoid contents for beneficial applications. The pigments were extracted by an optimized solvent system, purified by flash chromatography and were identified by TLC and UV/VIS spectroscopy. The absorbance spectra confirmed the presence of β-carotene, β-cryptoxanthin, torulene and torularhodin that showed maximum absorbance (λmax ) within the ranges. The fractions were further characterized by LC/MS and analyzed through FT-IR and NMR for structure elucidation. Spectral analyses also confirmed the presence of the compounds mentioned above. These compounds promise great commercial value and could be useful for large scale production anticipated for potential applications in food, nutraceutical, pharmaceutical and cosmetic sectors. It is pertinent that the characterized carotenoid pigments from the isolate have incredible prospects in industrial applications which require profound attention.
7 citations
TL;DR: Two series of thiazinone and thiosemicarbazone derivatives (1-12) were synthesized using 2,4-diaryl-3-azabicyclo[3.3.1]nonan-9-ones (ABNs) and 3-alkyl−2,6−diarylpiperidin-4-ones as the starting mat as discussed by the authors.
Abstract: Two series of thiazinone and thiosemicarbazone derivatives (1-12) were synthesized using 2,4-diaryl-3-azabicyclo[3.3.1]nonan-9-ones (ABNs) and 3–alkyl–2,6–diarylpiperidin–4–ones as the starting mat...
1 citations
TL;DR: A series of ropivacaine analogues synthesized by altering the methyl group substituent in the aromatic ring have shown a good inhibitory activity against breast cancer cell line and moderate antioxidant activity.
Abstract: A series of ropivacaine analogues were synthesized by altering the methyl group substituent in the aromatic ring. The synthesized
compounds (2a-f and 3a-f) were characterized by using IR, NMR and HRMS analysis and then compounds 3a-3f were screened in vitro
anticancer (MTT assay) activity against breast cancer cell line (MCF-7), antibacterial and antioxidant (DPPH scavenging assay) studies.
The biological studies revealed that the compounds 3c and 3f have shown a good inhibitory activity against MCF-7 cell line. Compounds
3e, 3b, 3c and 3f showed moderate antioxidant activity. There was no inhibition observed against both Gram-positive and Gram-negative
bacteria.
TL;DR: Quality control procedures to manage these impurities were developed to acquire the mass medication of ICH grade quality to create sensible analytical methods and set the quality standard for a quality control system in pharmaceutical manufacturing.
Abstract: Fosphenytoin sodium is a water dissolvable phenytoin prodrug that is directed intravenously to convey
phenytoin, conceivably more securely than intravenous phenytoin. It is most ordinarily utilized in the
intense treatment of convulsive status epileptics. The examination of the procedure-related contaminants
will not help exclusively to advance the process parameters yet additionally to create sensible analytical
methods and set the quality standard for a quality control system in pharmaceutical manufacturing.
During the production of fosphenytoin sodium, all the process-related impurities are controlled in
every stage and three degradation impurities are managed in the final API as per USP monograph.
Besides, five unknown and one known contaminants were detected by HPLC method. All these
impurities were identified, synthesized, isolated and characterized by IR, 1D-NMR (1H, 13C, DEPT)
and HRMS spectral techniques. The mechanism of the formed impurities is examined for the first
time. Quality control procedures to manage these impurities were developed to acquire the mass
medication of ICH grade quality.
03 Jul 2020
TL;DR: In this paper, a series of 1-allyl-2,6-diarylpiperidone $O$ -allyl oximes 13−18 were synthesized from 2,6diary lpiperidones through various steps.
Abstract: A new series of 1-allyl-2,6-diarylpiperidone $O$ -allyl oximes 13–18 were synthesized from 2,6-diarylpiperidones through various steps. The structures of all the compounds are characterized by their IR, NMR, (1D & 2D NMR) and mass spectral studies. Based on the spectral values and coupling constants all the compounds exist in chair conformation except 18 in boat conformation. Also, all the synthesized compounds are screened for their antimicrobial activity against several bacterial and fungal strains. p-Chloro-2,6-diphenyl substituted compound 15, showed remarkable activity against A.niger and compound 17 against Pseudomonas and A.flavus strains.