Showing papers by "Serge L. Beaucage published in 1991"

Alternating .alpha.,.beta.-oligothymidylates with alternating (3'.fwdarw.3')- and (5'.fwdarw.5')-internucleotidic phosphodiester linkages as models for antisense oligodeoxyribonucleotides

Abstract: Novel oligothymidylate analogues, achiral at phosphorus, exhibiting enhanced resistance to the action of nucleases and satisfactory hybridizing properties toward complementary DNA and RNA sequences, are proposed as models for antisense oligonucleotides