S
Sergey V. Balashov
Researcher at Public Health Research Institute
Publications - 9
Citations - 439
Sergey V. Balashov is an academic researcher from Public Health Research Institute. The author has contributed to research in topics: Biology & Drug resistance. The author has an hindex of 4, co-authored 5 publications receiving 418 citations.
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Journal ArticleDOI
Assessing Resistance to the Echinocandin Antifungal Drug Caspofungin in Candida albicans by Profiling Mutations in FKS1
TL;DR: Data support the importance of FKS1p substitutions in echinocandin resistance and demonstrate the feasibility of applying molecular screening for routine resistance assessment.
Journal ArticleDOI
Serum Differentially Alters the Antifungal Properties of Echinocandin Drugs
Padmaja Paderu,Guillermo Garcia-Effron,Sergey V. Balashov,Guillaume Delmas,Steven Park,David S. Perlin +5 more
TL;DR: Serum decreased the sensitivity of glucan synthase to echinocandin drugs and yielded nearly equivalent MICs or minimum effective concentrations against diverse Candida spp.
Journal ArticleDOI
Rapid, high-throughput, multiplex, real-time PCR for identification of mutations in the cyp51A gene of Aspergillus fumigatus that confer resistance to itraconazole.
TL;DR: In an effort to develop a new class of molecular diagnostic assay that can rapidly assess drug resistance, a multiplexed assay was established using molecular beacons corresponding to the wild-type cyp51A gene and seven mutant alleles encoding either Arg54, Lys54, Val54, Trp54, or Glu54.
Journal ArticleDOI
Regulation of Aggregatibacter (Actinobacillus) actinomycetemcomitans leukotoxin secretion by iron
TL;DR: Iron appears to play an important role in the regulation of LtxA secretion in A. actinomycetemcomitans in a manner independent of gene regulation.
Book ChapterDOI
Multiplex detection of mutations.
TL;DR: An application of a multiplexed real-time PCR assay using Molecular Beacon probes for the detection of mutations in codon 54 of the CYP51A gene in Aspergillus fumigatus conferring triazole resistance is described.