Seung-Nam Jung

TL;DR: Findings identify AMPK as a key determinant of HIF-1 functions in response to ROS and its possible role in the sophisticated Hif-1 regulatory mechanisms.

TL;DR: The findings suggest that the activation of the AMPK pathway might contribute to the development of novel therapeutic approaches for the treatment of metabolic disorders such as type 2 diabetes and obesity.

TL;DR: It is demonstrated that AMPK was rapidly activated in response to vanadate in DU145 human prostate carcinoma, and that its activation preceded HIF-1alpha expression, suggesting that AM PK is a novel and critical component of Hif-1 regulation.

TL;DR: It is demonstrated that Fas signaling in DU145 human prostate cancer cells leads to rapid activation of AMP-activated protein kinase (AMPK), which plays a major role in adaptive responses to ATP-depleting conditions, and inhibition of AMPK sensitizes DU145 cells to Fas-induced apoptosis via enhancement of ubiquitination and consequent proteasome degradation of the apoptosis inhibitory protein c-FLIP.

TL;DR: A high association with immune-escape signaling in the immune-hot group with aggressive clinical characteristics among Korean thyroid cancer patients is identified and HOXD9 was found to be a recurrence marker for advanced papillary thyroid cancer.