Sevasti B. Koukouritaki

TL;DR: The objective of this study was to characterize the developmental expression of hepatic CYP3A forms from early gestation to 18 years of age using up to 212 fetal and pediatric liver samples and based on immunoquantitation, CYP 3A5 protein expression was found to be highly variable, generally independent of age, and more frequently observed for African-American individuals.

TL;DR: The ontogeny of CYP2C9 and -2C19 were dissimilar among both fetal and 0- to 5-months postnatal samples, implying different developmental regulatory mechanisms.

TL;DR: The data suggest that birth is necessary, but not sufficient for the onset of FMO3 expression, and 2- to 20-fold interindividual variation in FMO1 and F MO3 protein levels were observed, depending on the age bracket.

TL;DR: The postnatal data suggest that infants less than 90 days old would have decreased clearance of CYP2E1 substrates compared with older infants, children, and adults.

TL;DR: It is demonstrated that in glomerular immune injury, hemin treatment upregulatesglomerular HO-1 with an attendant downregulation of iNOS expression, and thus points to regulatory interaction between the two systems.