Shang-Chuen Wu

TL;DR: The characterised dual binding modes demonstrate how binding potency, reported as decreased Kd values of the TDG inhibitors from μM to nM, is improved and also offer insights to development of selective inhibitors for individual galectins.

TL;DR: The RBD of SARS-CoV-2 shares sequence similarity with an ancient lectin family known to bind blood group antigens as mentioned in this paper, which can be used to directly link blood group A and SARS CoV2.

TL;DR: The first structural evidence of human galectins-1, 3-CRD and 7 in complex with LN1 was provided, with results indicated that the average glycosidic torsion angle of galectin-bound LN 1 was significantly differed from that of galECTin- bound LN2, i.e. the GlcNAc moiety adopted a different orientation to maintain essential interactions.

TL;DR: A method to selectively enrich serotonylated proteins in a complex sample using an alkyne-functionalized serotonin derivative bioorthogonally coupled to a cleavable linker to provide a great foundation in the elucidation of the true roles of proteinSerotonylation in biological systems is developed.

TL;DR: In this paper, the authors found that increased IgA anti-SARS-CoV-2 antibody levels correlated with clinical improvement and viral clearance in an infant with COVID-19, prompting a broader examination of IgA levels among convalescent plasma donors and hospitalized patients.