S
Sharon A. Creason
Researcher at University of Washington
Publications - 17
Citations - 733
Sharon A. Creason is an academic researcher from University of Washington. The author has contributed to research in topics: Trypanosoma brucei & Chemistry. The author has an hindex of 10, co-authored 14 publications receiving 629 citations. Previous affiliations of Sharon A. Creason include Fred Hutchinson Cancer Research Center.
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Journal ArticleDOI
Identification of a Metabolically Stable Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Antimalarial Activity in Mice
Ramesh Gujjar,Alka Marwaha,Farah El Mazouni,John H. White,Karen L. White,Sharon A. Creason,David M. Shackleford,Jeffrey Baldwin,William N. Charman,Frederick S. Buckner,Susan A. Charman,Pradip Rathod,Margaret A. Phillips +12 more
TL;DR: This study provides the first proof of concept that DH ODH inhibitors can suppress Plasmodium growth in vivo, validating DHODH as a new target for antimalarial chemotherapy.
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Lead-optimization of aryl and aralkyl amine based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice
Ramesh Gujjar,Farah El Mazouni,Karen L. White,John H. White,Sharon A. Creason,David M. Shackleford,Xiaoyi Deng,William N. Charman,Ian Bathurst,Jeremy N. Burrows,David M. Floyd,David Matthews,Frederick S. Buckner,Susan A. Charman,Margaret A. Phillips,Pradipsinh K. Rathod +15 more
TL;DR: Systematic efforts to optimize the aromatic functionality with the goal of improving potency and in vivo properties of compounds from the triazolopyrimidine-based Plasmodium falciparum dihydroorotate dehydrogenase-based series led to the identification of two new substituted aniline moieties.
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Bcl-2 Slowsin VitroBreast Cancer Growth Despite Its Antiapoptotic Effect
Katya Knowlton,Katya Knowlton,Mariangela Mancini,Mariangela Mancini,Sharon A. Creason,Sharon A. Creason,Cecile Morales,David M. Hockenbery,Benjamin O. Anderson,Benjamin O. Anderson +9 more
TL;DR: Despite antiapoptotic effects favoring tumor survival, Bcl-2 prolongs cell cycle and may account for the association of BCl-2 expression with a favorable outcome in breast cancer, even though B cl-2 may mediate chemoresistance in some patients.
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Substituted 2-phenylimidazopyridines: a new class of drug leads for human African trypanosomiasis.
Hari Babu Tatipaka,J. Robert Gillespie,Arnab K. Chatterjee,Neil R. Norcross,Matthew A. Hulverson,Ranae M. Ranade,Pendem Nagendar,Sharon A. Creason,Joshua McQueen,Nicole A. Duster,Advait Nagle,Frantisek Supek,Valentina Molteni,Tanja Wenzler,Tanja Wenzler,Reto Brun,Reto Brun,Richard Glynne,Frederick S. Buckner,Michael H. Gelb +19 more
TL;DR: Compound 64 cured mice infected with Trypanosoma brucei when dosed orally down to 2.5 mg/kg and represents a new lead for the development of drugs to treat human African trypanosomiasis.
Journal ArticleDOI
Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase
Alka Marwaha,John H. White,Farah El Mazouni,Sharon A. Creason,Sreekanth Kokkonda,Frederick S. Buckner,Susan A. Charman,Margaret A. Phillips,Pradipsinh K. Rathod +8 more
TL;DR: In this paper, a triazolopyrimidine-based inhibitor of P. falciparum dihydroorotate dehydrogenase was proposed. But this inhibitor showed good activity in mice.