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Shetuan Zhang
Researcher at Queen's University
Publications - 66
Citations - 2380
Shetuan Zhang is an academic researcher from Queen's University. The author has contributed to research in topics: hERG & Potassium channel. The author has an hindex of 27, co-authored 59 publications receiving 2157 citations. Previous affiliations of Shetuan Zhang include Tokyo Medical and Dental University & University of British Columbia.
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Journal ArticleDOI
Mechanism of Block and Identification of the Verapamil Binding Domain to HERG Potassium Channels
TL;DR: Verapamil enters the cell membrane in the neutral form to act at a site within the pore accessible from the intracellular side of the cell membranes, possibly involving the serine at position 620, and this may contribute to its antiarrhythmic mechanism.
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Block of HERG Potassium Channels by the Antihistamine Astemizole and its Metabolites Desmethylastemizole and Norastemizole
TL;DR: The objective in the present work was to study the effects of desmethylastemizole, norastemIZole, and astemizole on HERG K+ channels.
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Extracellular K+ concentration controls cell surface density of IKr in rabbit hearts and of the HERG channel in human cell lines.
Jun Guo,Hamid Massaeli,Jianmin Xu,Zongchao Jia,Jeffrey T. Wigle,Nasrin Mesaeli,Shetuan Zhang +6 more
TL;DR: The results provide the first evidence to the authors' knowledge that the cell surface density of a voltage-gated K+ channel, HERG, is regulated by a biological factor, extracellular K+.
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Droperidol Lengthens Cardiac Repolarization due to Block of the Rapid Component of the Delayed Rectifier Potassium Current
Benoit Drolet,Shetuan Zhang,Dominic Deschênes,Jimmy Rail,Sylvie Nadeau,Zhengfeng Zhou,Craig T. January,Jacques Turgeon +7 more
TL;DR: The effects of droperidol on cardiac repolarization are characterized and a major time‐dependent outward potassium current involved in cardiacRepolarization (IKr) is evaluated.
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Identification of IKr and its trafficking disruption induced by probucol in cultured neonatal rat cardiomyocytes
Jun Guo,Hamid Massaeli,Wentao Li,Jianmin Xu,Tao Luo,James Shaw,Lorrie A. Kirshenbaum,Shetuan Zhang +7 more
TL;DR: It is concluded that probucol induces LQTS by disrupting ether-a-go- go-related gene trafficking, and that primary culture of neonatal rat cardiomyocytes represents a useful system for studying native IKr trafficking.