Shigenobu Aoyagi

TL;DR: The utility of nano eye-drops utilising brinzolamide, a commercially available glaucoma treatment drug, as a target compound, is described, with results in high drug efficacy and applications as a next-generation ophthalmic treatment.

TL;DR: In this article, aldehydes and selenoketones were generated in situ by using bis(1,5-cyclooctanediylboryl) selenide; the resulting selenocarbonyl compounds were trapped with 2,3dimethyl-1,3-butadiene to give the corresponding [4+2] cycloadducts.

TL;DR: In this article, thermal cycloreversion of 6H-1,3,5-oxathiazines or 1,3-selenaza-1.3-butadienes with substitutions at the C-2 and C-4 positions was used to obtain 1,4-adducts of the heterodienes in the presence of nucleophiles.

TL;DR: In this paper, a pathway involving hetero-Diels-Alder reaction of isotellurazoles and the subsequent tellurium extrusion from the intermediary cycloadducts was proposed.

TL;DR: In this paper, sterically crowded thione Soxides derived from d-camphor with Lawesson's reagent were treated with deoxygenation of the starting materials, and the mixtures were subjected to mCPBA oxidation to give the corresponding dithiirane S-oxides.