Shih Ku Lin

TL;DR: These data support polygenic contributions to methamphetamine dependence from genes that include those whose variants contribute to dependence on several addictive substances, success in quitting smoking, and mnemonic processes.

TL;DR: In Asian patients with average metabolism, the dose needed for clinical response may range between 150 mg/day for female non-smokers to 300 mg/ day for male smokers, which may help personalize dosing in clozapine poor metabolizer (PMs) and ultrarapid metabolizers (UMs).

TL;DR: Almost 10% of Asians may be clozapine PMs and may need only 50 to 150 mg/d to get therapeutic concentrations, and future studies combining gene sequencing for new alleles with repeated concentrations and careful control of confounders including inhibitors, inflammation, and obesity should provide better estimations of the prevalence of phenotypic clozAPinePMs across races.

TL;DR: The clinical rationale of clozapine prescription needs careful consideration in Asia with more local input because of the diverse prescription patterns found in Asian countries/territories.

TL;DR: This study examined the psychotropic prescription patterns in adult Asian schizophrenia patients based on the data of the Research on Asian Psychotropic Prescription (REAP) 2016 survey, which varied across countries.