S
Shimako Tanaka
Researcher at University of Shizuoka
Publications - 32
Citations - 242
Shimako Tanaka is an academic researcher from University of Shizuoka. The author has contributed to research in topics: Pharmacokinetics & Medicine. The author has an hindex of 8, co-authored 28 publications receiving 170 citations.
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Journal ArticleDOI
Simultaneous LC-MS/MS Analysis of the Plasma Concentrations of a Cocktail of 5 Cytochrome P450 Substrate Drugs and Their Metabolites
TL;DR: A rapid and selective LC-MS/MS method that enables in vivo assessment of the activity of various drug-metabolizing enzymes in a single assay is developed and validated.
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Chronological effects of rifampicin discontinuation on cytochrome P450 activity in healthy Japanese volunteers, using the cocktail method.
Naoki Inui,Taisuke Akamatsu,Shinya Uchida,Shimako Tanaka,Noriyuki Namiki,Masato Karayama,Kingo Chida,Hirofumi Watanabe +7 more
TL;DR: The chronological changes of rifampsicin‐induced CYP enzyme activities after rifampicin discontinuation is clarified to clarify the time course after drug treatment discontinuation.
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Quantitation of chafurosides A and B in tea leaves and isolation of prechafurosides A and B from oolong tea leaves.
TL;DR: Prechafurosides A and B were concluded to be new flavone C-glycoside sulfates, isovitex in-2''-sulfate and vitexin- 2''-Sulfate, respectively.
Journal ArticleDOI
Comparison of inhibitory duration of grapefruit juice on organic anion-transporting polypeptide and cytochrome P450 3A4.
Shimako Tanaka,Shinya Uchida,Sachiko Miyakawa,Naoki Inui,Kazuhiko Takeuchi,Hiroshi Watanabe,Noriyuki Namiki +6 more
TL;DR: Results of this study indicated that the OATP inhibition caused by GFJ dissipated faster than GFJ-mediated alterations in CYP3A4 activity, which were sustained for at least 48 h.
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Effect of co-administered inducer or inhibitor on omeprazole pharmacokinetics based on CYP2C19 genotype
Chiaki Kamiya,Naoki Inui,Akio Hakamata,Sachiko Miyakawa,Shimako Tanaka,Shinya Uchida,Noriyuki Namiki,Keiichi Odagiri,Hiroshi Watanabe +8 more
TL;DR: The genotyping of CYP2C19 may be useful for predicting drug interactions with metabolic inhibitors, and rifampicin increased omeprazole metabolism in all subjects irrespective of genotype, which suggested that CYP1C19 enzymatic activity was induced by rifampsicin administration for all genotypes.