S
Sibei Lei
Researcher at Sichuan University
Publications - 9
Citations - 107
Sibei Lei is an academic researcher from Sichuan University. The author has contributed to research in topics: Medicine & Genetic enhancement. The author has an hindex of 3, co-authored 5 publications receiving 14 citations.
Papers
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Journal ArticleDOI
Efficient Colorectal Cancer Gene Therapy with IL-15 mRNA Nanoformulation.
Sibei Lei,Xueyan Zhang,Ke Men,Yan Gao,Xijing Yang,Sisi Wu,Xingmei Duan,Yuquan Wei,Rongsheng Tong +8 more
TL;DR: The results demonstrated that the prepared CLPP system could deliver IL-15 encoding mRNA into C26 cells with high efficacy and triggered anti-cancer cytotoxicity upon cancer cells in vitro.
Journal ArticleDOI
Treatment of Colon Cancer by Degradable rrPPC Nano-Conjugates Delivered STAT3 siRNA.
Hongjia Zhang,Ke Men,Congbin Pan,Yan Gao,Jingmei Li,Sibei Lei,Guonian Zhu,Rui Li,Yuquan Wei,Xingmei Duan +9 more
TL;DR: Evidence is provided that rrPPC nanoparticles constitute a potential candidate vector for siRNA-based colon cancer gene therapy, as well as loading the signal transducer and activator of transcription 3 targeting siRNA, which demonstrated strong anti-cancer effects in multiple colon cancer models following local delivery.
Journal ArticleDOI
Small molecules in the treatment of COVID-19
TL;DR: In this paper , the authors discuss the current findings in the development of small molecules for COVID-19 treatment, including their detailed mechanism of action, chemical structures, and preclinical and clinical efficacies.
Journal ArticleDOI
Current Progress in Messenger RNA-Based Gene Therapy.
TL;DR: Based on its rapid expression, simple sequence composition, low immunogenicity, and flexible modification possibilities, in vitro synthesized mRNA has demonstrated strong potential as a candidate for gene therapy.
Journal ArticleDOI
Functionalized DMP-039 Hybrid Nanoparticle as a Novel mRNA Vector for Efficient Cancer Suicide Gene Therapy.
Yan Gao,Ke Men,Congbin Pan,Jingmei Li,Jieping Wu,Xiaohua Chen,Sibei Lei,Xiang Gao,Xingmei Duan +8 more
TL;DR: In this paper, an advanced mRNA delivery system, DMP-039, was developed by fusing a cell-penetrating peptide, cRGD-R9, and a cationic nano-sized DMP backbone together.