Erectile Dysfunction: AUA Guideline.

Background Erectile dysfunction (ED) shares similar modifiable risks factors with coronary artery disease (CAD). Lifestyle modification that targets CAD risk factors may also lead to improvement in ED. We conducted a systematic review and meta-analysis of randomized controlled trials evaluating the effect of lifestyle interventions and pharmacotherapy for cardiovascular (CV) risk factors on the severity of ED. Methods A comprehensive search of multiple electronic databases through August 2010 was conducted using predefined criteria. We included randomized controlled clinical trials with follow-up of at least 6 weeks of lifestyle modification intervention or pharmacotherapy for CV risk factor reduction. Studies were selected by 2 independent reviewers. The main outcome measure of the study is the weighted mean differences in the International Index of Erectile Dysfunction (IIEF-5) score with 95% confidence intervals (CIs) using a random effects model. Results A total of 740 participants from 6 clinical trials in 4 countries were identified. Lifestyle modifications and pharmacotherapy for CV risk factors were associated with statistically significant improvement in sexual function (IIEF-5 score): weighted mean difference, 2.66 (95% CI, 1.86-3.47). If the trials with statin intervention (n = 143) are excluded, the remaining 4 trials of lifestyle modification interventions (n = 597) demonstrate statistically significant improvement in sexual function: weighted mean difference, 2.40 (95% CI, 1.19-3.61). Conclusion The results of our study further strengthen the evidence that lifestyle modification and pharmacotherapy for CV risk factors are effective in improving sexual function in men with ED.

https://jamanetwork.com/journals/jamainternalmedicine/articlepdf/1106016/ira15008_1797_1803.pdf

The Effect of Lifestyle Modification and Cardiovascular Risk Factor Reduction on Erectile Dysfunction: A Systematic Review and Meta-analysis

Purpose C-reactive protein (CRP) is a marker of chronic systemic inflammation frequently used in cardiovascular disease risk assessment. The purpose of this meta-analysis was to provide a quantitative estimate of the magnitude of change in CRP following participation in physical exercise interventions. Methods All studies included in the meta-analysis were peer reviewed and published in English. Human participants were assigned to a non-exercise comparison group or exercise training group, with the intervention lasting ≥2 weeks. CRP levels were measured at baseline, during and/or after completion of the exercise training programme. Random-effects models were used to aggregate a mean effect size (ES), 95% CIs and potential moderators. Results 83 randomised and non-randomised controlled trials met the inclusion criteria and resulted in 143 effects (n=3769). The mean ES of 0.26 (95% CI 0.18 to 0.34, p Conclusions These results suggest that engaging in exercise training is associated with a decrease in CRP levels regardless of the age or sex of the individual; however, greater improvements in CRP level occur with a decrease in BMI or %Fat.

https://bjsm.bmj.com/content/bjsports/early/2016/07/27/bjsports-2016-095999.full.pdf

Effect of exercise training on C reactive protein: a systematic review and meta-analysis of randomised and non-randomised controlled trials

British Society for Sexual Medicine Guidelines on the Management of Erectile Dysfunction in Men-2017

Erectile dysfunction (ED) is a common medical disorder whose prevalence is increasing worldwide. Modifiable risk factors for ED include smoking, lack of physical activity, wrong diets, overweight or obesity, metabolic syndrome, and excessive alcohol consumption. Quite interestingly, all these metabolic conditions are strongly associated with a pro-inflammatory state that results in endothelial dysfunction by decreasing the availability of nitric oxide (NO), which is the driving force of the blood genital flow. Lifestyle and nutrition have been recognized as central factors influencing both vascular NO production, testosterone levels, and erectile function. Moreover, it has also been suggested that lifestyle habits that decrease low-grade clinical inflammation may have a role in the improvement of erectile function. In clinical trials, lifestyle modifications were effective in ameliorating ED or restoring absent ED in people with obesity or metabolic syndrome. Therefore, promotion of healthful lifestyles would yield great benefits in reducing the burden of sexual dysfunction. Efforts, in order to implement educative strategies for healthy lifestyle, should be addressed.

Lifestyle modifications and erectile dysfunction: what can be expected?

The purpose of the present study was to determine the effect of an interval exercise training program on C-reactive protein and erectile dysfunction (ED) management in older male hypertensive patients. Twenty-two male hypertensive patients with ED (n=22; 62.10+/-5.23 years) were involved in interval exercise training (60%-79% heart rate max reserve) for 8 weeks for a duration of between 45 to 60 min/d, while an age-matched control hypertensive (n=21; 64.00+/-4.77 years) group remained sedentary during this period. The study revealed a significant effect of an exercise training program on erectile function of hypertensive patients with ED (P<.05). It was concluded that an exercise program is a possible effective noninvasive and nonpharmacologic management of ED in male hypertensive patients.

https://www.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1751-7176.2009.00086.x

Therapeutic Effect of an Interval Exercise Training Program in the Management of Erectile Dysfunction in Hypertensive Patients

Objective: Elevated serum uric acid is considered to be positively associated with cardiovascular event risk factor in hypertension. Also, the positive role of exercise in the management of Hypertension has been well and long established. However the relationship between serum uric acid (SUA) level and hypertensive management particularly in non pharmacological technique is ambiguous and unclear. Therefore the purpose of the present study was to determine the effect of interval training programme on serum uric acid level and cardiovascular parameters in male subjects with hypertension. Methods: Two hundred and forty five male patients with mild to moderate (systolic blood pressure (SBP) between 140-180 and diastolic blood pressure (DBP) between 90-109 mmHg) essential hypertension were age matched and grouped into interval and control groups. The interval (n=140; 58.90 ± 7.35 years) group involved in an 8 weeks interval training (60-79% HR max reserve) programme of between 45minutes to 60 minutes at a work/rest ratio of 1:1of 6 minutes each, while age-matched controls hypertensive (n=105; 58.27± 6.24 years) group remain sedentary during this period. Cardiovascular parameters (SBP, DBP and VO2max) and serum uric acid were assessed. Students' t and Pearson correlation tests were used in data analysis. Results: Findings of the study revealed significant effect of interval training programme on VO 2 max, SBP, DBP and serum uric acid level at p< 0.05.Also there was significant correlation between changes VO 2 max and changes in SUA, SBP and DBP Conclusions: It was concluded that interval training programme is an effective non-pharmacological means of downregulation of SUA.

Uricaemia as a cardiovascular events risk factor in hypertension: the role of interval training programme in its downregulation.

Objective: The objective of this study was to determine the effects of 5mg/kg dose of caffeine on maximal aerobic power of normal young male African (Nigerian) adults.
 Method: Twenty normal young male adults volunteers participated. A repeated measure 2 randomized crossover (counter balanced) double blind design was used in data collection. Subjects engaged in 20 meter shuttle run test (20 MST) one hour Post caffeine (5mg.kg-1) and placebo doses ingestion. Endurance Performance indexes (VO2 max, run time and number of exercise laps) were recorded. Result : Repeated measures t-test was used to assess the level of significant difference between caffeine doses and placebo dose in VO2 max,run time and number of exercise laps. The result showed no significant effect of caffeine doses over placebo dose at P Conclusion : It was concluded that instant soluble coffee (Caffeine) dose of 5mg/kg (300mg caffeine) seems not have any ergogenic effect on max aerobic power of normal young black male African Adults.
 Key words : Coffee, Caffeine, Exercise, black African, ergogenic

/pdf/ergogenic-effects-of-caffeine-dose-on-maximal-aerobic-power-2ovd8t94uo.pdf

Sikiru Lamina

Papers

Therapeutic Effect of an Interval Exercise Training Program in the Management of Erectile Dysfunction in Hypertensive Patients

Uricaemia as a cardiovascular events risk factor in hypertension: the role of interval training programme in its downregulation.

Ergogenic effects of caffeine dose on maximal aerobic power of normal nigerian undergraduate students.