Silvio R. Bareggi

TL;DR: This review of the literature concerning the relationships between plasma concentrations of SGAs and clinical responses is divided by dividing the studies on the basis of the length of their observation periods by indicating a relationship between clinical outcomes and plasma concentrations.

TL;DR: The first methods for determining plasma and tissue clioquinol levels were set up in the 1970s and involved HPLC separation with UV detection, followed by a more sensitive GC method with electron capture detection and a gaschromatographic‐massspectrometric method, which has proved to be as highly sensitive and specific as the GC‐MS.

TL;DR: The decrease in HVA level was more pronounced in patients with severe mental deterioration and therefore appeared to be disease related, when compared with the age-matched controls.

TL;DR: A need for a more balanced assessment of the benefits and risks associated with benzodiazepine use, particularly considering pharmacokinetic profile of the drugs to ensure that patients, who would truly benefit from these agents, are not denied appropriate treatment.

TL;DR: The results seem to suggest the importance of pharmacodynamic, constitutional, and genetic data over strict pharmacokinetics in determining the clinical response to CLZ.