Simone Cappelletti

TL;DR: The present review summarizes the main findings concerning caffeine’s mechanisms of action, use, abuse, dependence, intoxication, and lethal effects, and suggests that the concepts of toxic and lethal doses are relative.

TL;DR: Although caffeine intoxication is relatively uncommon, raising awareness about its lethal consequences could be useful for both clinicians and pathologists to identify possible unrecognized cases and prevent related severe health conditions and deaths.

TL;DR: Raising awareness about the encountered mean body levels of the drugs and the typical imaging signs of the incorporated packages could be useful for clinicians and forensic pathologists to identify possible unrecognized cases of body packing and prevent the serious health consequences and deaths frequently occurring after the packages’ leakage or rupture or the packages' mass obstructing the gastrointestinal lumen.

TL;DR: A better understanding of the mechanisms of sepsis-associated TTC may generate novel strategies to treat the complications of this cardiomyopathy and may even help predict and prevent its occurrence.

TL;DR: A standardized approach for the description of drug packages based on the use of different materials and packaging procedures is suggested, which provide a possible insight to the type of drug trafficking organization involved.