S
Sinead Cuffe
Researcher at Princess Margaret Cancer Centre
Publications - 71
Citations - 9718
Sinead Cuffe is an academic researcher from Princess Margaret Cancer Centre. The author has contributed to research in topics: Lung cancer & Cancer. The author has an hindex of 16, co-authored 61 publications receiving 6898 citations. Previous affiliations of Sinead Cuffe include University of Toronto.
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Journal ArticleDOI
Pembrolizumab versus Chemotherapy for PD-L1–Positive Non–Small-Cell Lung Cancer
Martin Reck,Delvys Rodriguez-Abreu,Andrew G. Robinson,Rina Hui,Tibor Csőszi,Andrea Fülöp,Maya Gottfried,Nir Peled,Ali Tafreshi,Sinead Cuffe,Mary O'Brien,Suman Rao,Katsuyuki Hotta,Melanie A. Leiby,Gregory M. Lubiniecki,Yue Shentu,Reshma A. Rangwala,Julie R. Brahmer +17 more
TL;DR: Pembrolizumab is a humanized monoclonal antibody against programmed death 1 (PD-1) that has antitumor activity in advanced non-small-cell lung cancer (NSCLC), with increased activity in tumors that express PD-L1 as mentioned in this paper.
Journal ArticleDOI
Updated Analysis of KEYNOTE-024: Pembrolizumab Versus Platinum-Based Chemotherapy for Advanced Non–Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score of 50% or Greater
Martin Reck,Delvys Rodriguez-Abreu,Andrew G. Robinson,Rina Hui,Tibor Csoszi,Andrea Fülöp,Maya Gottfried,Nir Peled,Ali Tafreshi,Sinead Cuffe,Mary O'Brien,Suman Rao,Katsuyuki Hotta,Kristel Vandormael,Antonio Riccio,J. Yang,M. Catherine Pietanza,Julie R. Brahmer +17 more
TL;DR: With prolonged follow-up, first-line pembrolizumab monotherapy continues to demonstrate an OS benefit over chemotherapy in patients with previously untreated, advanced NSCLC without EGFR/ALK aberrations, despite crossover from the control arm to pembrolezumab as subsequent therapy.
Journal ArticleDOI
Five-Year Outcomes With Pembrolizumab Versus Chemotherapy for Metastatic Non-Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score >= 50%
Martin Reck,Delvys Rodriguez-Abreu,Andrew G. Robinson,Rina Hui,Tibor Csőszi,Andrea Fülöp,Maya Gottfried,Nir Peled,Ali Tafreshi,Sinead Cuffe,Mary O'Brien,Suman Rao,Katsuyuki Hotta,Ticiana A. Leal,Jonathan W. Riess,Erin Jensen,Bin Zhao,M. Catherine Pietanza,Julie R. Brahmer +18 more
TL;DR: The first 5-year follow-up of any first-line phase III immunotherapy trial for non-small-cell lung cancer (NSCLC) was reported in this article.
Journal ArticleDOI
Health-related quality-of-life results for pembrolizumab versus chemotherapy in advanced, PD-L1-positive NSCLC (KEYNOTE-024): a multicentre, international, randomised, open-label phase 3 trial
Julie R. Brahmer,Delvys Rodriguez-Abreu,Andrew G. Robinson,Rina Hui,Tibor Csőszi,Andrea Fülöp,Maya Gottfried,Nir Peled,Ali Tafreshi,Sinead Cuffe,Mary O'Brien,Suman Rao,Katsuyuki Hotta,Jin Zhang,Gregory M. Lubiniecki,Anne C. Deitz,Reshma A. Rangwala,Martin Reck +17 more
TL;DR: The prespecified exploratory endpoint of pembrolizumab versus chemotherapy on patient-reported outcomes (PROs) was baseline-to-week-15 change in the GHS/quality-of-life (QOL) score and time to deterioration of the composite of cough, chest pain, and dyspnoea in the QLQ-LC13.
Journal ArticleDOI
Erlotinib and bevacizumab in patients with advanced non-small-cell lung cancer and activating EGFR mutations (BELIEF): an international, multicentre, single-arm, phase 2 trial
Rafael Rosell,Urania Dafni,Enriqueta Felip,Alessandra Curioni-Fontecedro,Oliver Gautschi,Solange Peters,Bartomeu Massuti,Ramon Palmero,Santiago Ponce Aix,Enric Carcereny,Martin Früh,Miklos Pless,Sanjay Popat,Athanasios Kotsakis,Sinead Cuffe,Paolo Bidoli,Adolfo Favaretto,Patrizia Froesch,Noemi Reguart,Javier Puente,Linda Coate,Fabrice Barlesi,Daniel Rauch,Michael Thomas,Carlos Camps,José Gómez-Codina,Margarita Majem,Rut Porta,Riyaz Shah,Emer Hanrahan,Roswitha Kammler,Barbara Ruepp,Manuela Rabaglio,M. Kassapian,Niki Karachaliou,Rachel Tam,David S. Shames,Miguel Angel Molina-Vila,Rolf A. Stahel +38 more
TL;DR: The BELIEF trial provides further evidence of benefit for the combined use of erlotinib and bevacizumab in patients with NSCLC harbouring activating EGFR mutations.