S
Siobhan Brennan
Researcher at Queen's University Belfast
Publications - 5
Citations - 312
Siobhan Brennan is an academic researcher from Queen's University Belfast. The author has contributed to research in topics: Oxidative stress & Malondialdehyde. The author has an hindex of 4, co-authored 5 publications receiving 290 citations.
Papers
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Journal ArticleDOI
Increased oxidative stress in Alzheimer's disease as assessed with 4-hydroxynonenal but not malondialdehyde.
Lawrence T. McGrath,B M McGleenon,Siobhan Brennan,D McColl,Stephen P. McIlroy,Anthony Peter Passmore +5 more
TL;DR: Increased production of 4-HNE indicates increased oxidative stress (lipid peroxidation), which is not evident using the more common marker MDA, and was related to the degree of cognitive impairment (MMSE).
Journal ArticleDOI
Platelet β-secretase activity is increased in Alzheimer's disease
Janet A. Johnston,W.W. Liu,D.T.R. Coulson,Stephen Todd,Suzanne P. Murphy,Siobhan Brennan,C.J. Foy,David Craig,G.B. Irvine,Anthony Peter Passmore +9 more
TL;DR: A significant 17% increase in platelet membrane β-secretase activity was identified in individuals with AD compared to controls, indicating that the increase did not occur as a secondary result of the disease process, and may even have preceded symptom onset.
Journal Article
beta-Secretase Activity in Human Platelets
Journal ArticleDOI
P3-024 β-secretase activity in human platelets
Journal ArticleDOI
Individuals with cystic fibrosis do not display impaired endothelial function or evidence of oxidative damage in endothelial cells exposed to serum.
Lawrence T. McGrath,Damien O. McCall,C G Hanratty,Siobhan Brennan,Adrian Devine,Daniel F. McCAULEY,Bernard Silke,Stuart Elborn +7 more
TL;DR: Despite evidence for heightened systemic oxidative stress in CF, patients displayed no impairment of endothelial function, and their serum caused significantly less damage to human endothelial cells than that from matched controls.