S
Solveig Boehnke
Researcher at Leipzig University
Publications - 6
Citations - 120
Solveig Boehnke is an academic researcher from Leipzig University. The author has contributed to research in topics: Phosphoramidite & Peptide synthesis. The author has an hindex of 5, co-authored 6 publications receiving 107 citations.
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Journal ArticleDOI
Receptor-Mediated Uptake of Boron-Rich Neuropeptide Y Analogues for Boron Neutron Capture Therapy
Verena M. Ahrens,René Frank,Solveig Boehnke,C. Schütz,G. Hampel,Dorothee Iffland,Nicolas H. Bings,Evamarie Hey-Hawkins,Annette G. Beck-Sickinger +8 more
TL;DR: Boron uptake studies by inductively coupled plasma mass spectrometry revealed successful uptake of the multi‐carbaborane peptide into hY1‐receptor‐expressing cells, exceeding the required amount of 109 boron atoms per cell, demonstrating that the NPY/hY receptor system can act as an effective transport system for borOn‐containing moieties.
Journal ArticleDOI
Charge-Compensated Metallacarborane Building Blocks for Conjugation with Peptides.
TL;DR: The synthesis of an imidazolium‐based charge‐compensated cobalt bis(dicarbollide) building block, which allows additional modifications with moieties of biochemical relevance, such as monosaccharides, is reported.
Journal ArticleDOI
Carbaboranes – more than just phenyl mimetics
René Frank,Verena M. Ahrens,Solveig Boehnke,Sven Hofmann,Martin Kellert,Stefan Saretz,Souvik Pandey,Menyhárt B. Sárosi,Ágota Bartók,Annette G. Beck-Sickinger,Evamarie Hey-Hawkins +10 more
Abstract: Abstract Dicarba-closo-dodecaboranes(12) (C2B10H12, carbaboranes) are highly hydrophobic and stable icosahedral carbon-containing boron clusters. The cage framework of these clusters can be modified with a variety of substituents, both at the carbon and at the boron atoms. Substituted carbaboranes are of interest in medicine as boron neutron capture therapy (BNCT) agents or as pharmacophores. High and selective accumulation in tumour cells is an important requirement for a BNCT agent and is achieved by incorporating boron-rich, water-soluble carbaborane derivatives into breast tumour-selective modified neuropeptide Y, [F7, P34]-NPY. Preliminary studies showed that the receptor binding affinity and signal transduction of the boron-modified peptides were very well retained. Use of carbaboranes as pharmacophores was shown by replacement of Bpa32 (Bpa=benzoylphenylalanine) in the reduced-size NPY analogue [Pro30, Nle31, Bpa32, Leu34]-NPY 28–36 by ortho-carbaboranyl propanoic acid. The inclusion of the carbaborane derivative resulted in a short NPY agonist with an interesting hY2R/hY4R preference. This might be a promising approach in the field of anti-obesity drug development.
Journal ArticleDOI
From ortho -carbaborane-9-thiol towards new building blocks
TL;DR: In this paper, a bis-galactosyl-substituted ortho-carbaborane carboxylic acid was proposed as a general approach towards carbaboranes with three substituents.
Journal ArticleDOI
Imitation and modification of bioactive lead structures via integration of boron clusters
Sven Stadlbauer,René Frank,Matthias Scholz,Solveig Boehnke,Verena M. Ahrens,Annette G. Beck-Sickinger,Evamarie Hey-Hawkins +6 more
TL;DR: A suitable synthesis employing the phosphoramidite method to connect meta-carbaboranyl bis-phosphonites with the 6'-OH group of isopropylidene-protected galactose, followed by oxidation or sulfurization to give the corresponding bis- phosphonates is developed.