Automated medical image analysis is an emerging field of research that identifies the disease with the help of imaging technology. Diabetic retinopathy (DR) is a retinal disease that is diagnosed in diabetic patients. Deep neural network (DNN) is widely used to classify diabetic retinopathy from fundus images collected from suspected persons. The proposed DR classification system achieves a symmetrically optimized solution through the combination of a Gaussian mixture model (GMM), visual geometry group network (VGGNet), singular value decomposition (SVD) and principle component analysis (PCA), and softmax, for region segmentation, high dimensional feature extraction, feature selection and fundus image classification, respectively. The experiments were performed using a standard KAGGLE dataset containing 35,126 images. The proposed VGG-19 DNN based DR model outperformed the AlexNet and spatial invariant feature transform (SIFT) in terms of classification accuracy and computational time. Utilization of PCA and SVD feature selection with fully connected (FC) layers demonstrated the classification accuracies of 92.21%, 98.34%, 97.96%, and 98.13% for FC7-PCA, FC7-SVD, FC8-PCA, and FC8-SVD, respectively.

Fundus Image Classification Using VGG-19 Architecture with PCA and SVD

The fields of medicine science and health informatics have made great progress recently and have led to in-depth analytics that is demanded by generation, collection and accumulation of massive data. Meanwhile, we are entering a new period where novel technologies are starting to analyze and explore knowledge from tremendous amount of data, bringing limitless potential for information growth. One fact that cannot be ignored is that the techniques of machine learning and deep learning applications play a more significant role in the success of bioinformatics exploration from biological data point of view, and a linkage is emphasized and established to bridge these two data analytics techniques and bioinformatics in both industry and academia. This survey concentrates on the review of recent researches using data mining and deep learning approaches for analyzing the specific domain knowledge of bioinformatics. The authors give a brief but pithy summarization of numerous data mining algorithms used for preprocessing, classification and clustering as well as various optimized neural network architectures in deep learning methods, and their advantages and disadvantages in the practical applications are also discussed and compared in terms of their industrial usage. It is believed that in this review paper, valuable insights are provided for those who are dedicated to start using data analytics methods in bioinformatics.

A Survey of Data Mining and Deep Learning in Bioinformatics

Machine learning and artificial intelligence based Diabetes Mellitus detection and self-management: A systematic review

Diabetic retinopathy (DR) is a complication of diabetes that exists throughout the world. DR occurs due to a high ratio of glucose in the blood, which causes alterations in the retinal microvasculature. Without preemptive symptoms of DR, it leads to complete vision loss. However, early screening through computer-assisted diagnosis (CAD) tools and proper treatment have the ability to control the prevalence of DR. Manual inspection of morphological changes in retinal anatomic parts are tedious and challenging tasks. Therefore, many CAD systems were developed in the past to assist ophthalmologists for observing inter- and intra-variations. In this paper, a recent review of state-of-the-art CAD systems for diagnosis of DR is presented. We describe all those CAD systems that have been developed by various computational intelligence and image processing techniques. The limitations and future trends of current CAD systems are also described in detail to help researchers. Moreover, potential CAD systems are also compared in terms of statistical parameters to quantitatively evaluate them. The comparison results indicate that there is still a need for accurate development of CAD systems to assist in the clinical diagnosis of diabetic retinopathy.

https://www.mdpi.com/2073-8994/11/6/749/pdf

Recent Development on Detection Methods for the Diagnosis of Diabetic Retinopathy

Diabetic retinopathy (DR) is a diabetes complication that affects the eye and can cause damage from mild vision problems to complete blindness. It has been observed that the eye fundus images show various kinds of color aberrations and irrelevant illuminations, which degrade the diagnostic analysis and may hinder the results. In this research, we present a methodology to eliminate these unnecessary reflectance properties of the images using a novel image processing schema and a stacked deep learning technique for the diagnosis. For the luminosity normalization of the image, the gray world color constancy algorithm is implemented which does image desaturation and improves the overall image quality. The effectiveness of the proposed image enhancement technique is evaluated based on the peak signal to noise ratio (PSNR) and mean squared error (MSE) of the normalized image. To develop a deep learning based computer-aided diagnostic system, we present a novel methodology of stacked generalization of convolution neural networks (CNN). Three custom CNN model weights are fed on the top of a single meta-learner classifier, which combines the most optimum weights of the three sub-neural networks to obtain superior metrics of evaluation and robust prediction results. The proposed stacked model reports an overall test accuracy of 97.92% (binary classification) and 87.45% (multi-class classification). Extensive experimental results in terms of accuracy, F-measure, sensitivity, specificity, recall and precision reveal that the proposed methodology of illumination normalization greatly facilitated the deep learning model and yields better results than various state-of-art techniques.

/pdf/diabetic-retinopathy-diagnosis-from-fundus-images-using-13cih07gc6.pdf

Diabetic Retinopathy Diagnosis From Fundus Images Using Stacked Generalization of Deep Models

The main complication of diabetes is Diabetic retinopathy (DR), retinal vascular disease and it leads to the blindness. Regular screening for early DR disease detection is considered as an intensive labor and resource oriented task. Therefore, automatic detection of DR diseases is performed only by using the computational technique is the great solution. An automatic method is more reliable to determine the presence of an abnormality in Fundus images (FI) but, the classification process is poorly performed. Recently, few research works have been designed for analyzing texture discrimination capacity in FI to distinguish the healthy images. However, the feature extraction (FE) process was not performed well, due to the high dimensionality. Therefore, to identify retinal features for DR disease diagnosis and early detection using Machine Learning and Ensemble Classification method, called, Machine Learning Bagging Ensemble Classifier (ML-BEC) is designed. The ML-BEC method comprises of two stages. The first stage in ML-BEC method comprises extraction of the candidate objects from Retinal Images (RI). The candidate objects or the features for DR disease diagnosis include blood vessels, optic nerve, neural tissue, neuroretinal rim, optic disc size, thickness and variance. These features are initially extracted by applying Machine Learning technique called, t-distributed Stochastic Neighbor Embedding (t-SNE). Besides, t-SNE generates a probability distribution across high-dimensional images where the images are separated into similar and dissimilar pairs. Then, t-SNE describes a similar probability distribution across the points in the low-dimensional map. This lessens the Kullback-Leibler divergence among two distributions regarding the locations of the points on the map. The second stage comprises of application of ensemble classifiers to the extracted features for providing accurate analysis of digital FI using machine learning. In this stage, an automatic detection of DR screening system using Bagging Ensemble Classifier (BEC) is investigated. With the help of voting the process in ML-BEC, bagging minimizes the error due to variance of the base classifier. With the publicly available retinal image databases, our classifier is trained with 25% of RI. Results show that the ensemble classifier can achieve better classification accuracy (CA) than single classification models. Empirical experiments suggest that the machine learning-based ensemble classifier is efficient for further reducing DR classification time (CT).

Somasundaram S K

Papers

A Machine Learning Ensemble Classifier for Early Prediction of Diabetic Retinopathy.