Chitosan: Structural modification, biological activity and application.

Selenium (Se) is an essential element to human health that can be obtained in nature through several sources. In the human body, it is incorporated into selenocysteine, an amino acid used to synthesize several selenoproteins, which have an active center usually dependent on the presence of Se. Although Se shows several beneficial properties in human health, it has also a narrow therapeutic window, and therefore the excessive intake of inorganic and organic Se-based compounds often leads to toxicity. Nanoparticles based on Se (SeNPs) are less toxic than inorganic and organic Se. They are both biocompatible and capable of effectively delivering combinations of payloads to specific cells following their functionalization with active targeting ligands. Herein, the main origin of Se intake, its role on the human body, and its primary biomedical applications are revised. Particular focus will be given to the main therapeutic targets that are explored for SeNPs in cancer therapies, discussing the different functionalization methodologies used to improve SeNPs stability, while enabling the extensive delivery of drug-loaded SeNP to tumor sites, thus avoiding off-target effects.

Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics.

Chitosan: A review of molecular structure, bioactivities and interactions with the human body and micro-organisms.

Biomedical application of chitosan-based nanoscale delivery systems: Potential usefulness in siRNA delivery for cancer therapy.

In this paper, a spotlight is shown on polysaccharides based biomaterials which have surfaced as a versatile platform for different biomedical applications including drug delivery and tissue regeneration. Herein, structure and unique properties of different polysaccharides are described along with various functionalization strategies. Additionally, a brief overview of different physical and chemical crosslinking approaches to design polysaccharides derived biomaterials is provided. Due to their inherent biocompatible and biodegradable properties, polysaccharides based biomaterials are being extensively explored for performing a difficult task under complex biological environment. Hence, recent developments in using polysaccharides derived functional biomaterials especially for drug delivery and tissue engineering applications are described here. The studies reviewed here motivate to fabricate novel polysaccharides based biomaterials with outstanding properties and functionality. Finally, various future possibilities to achieve their widespread commercial use are discussed.

Recent advances in polysaccharides based biomaterials for drug delivery and tissue engineering applications

Effect of molecular weight of chitosan and its oligosaccharides on antitumor activities of chitosan-selenium nanoparticles.

Physicochemical stability and functional properties of selenium nanoparticles stabilized by chitosan, carrageenan, and gum Arabic.

Physicochemical and functional properties of chitosan-stabilized selenium nanoparticles under different processing treatments

The invention discloses a preparation method of a dehumidifying and formaldehyde-removing coffee residue air freshening bag. The preparation method comprises the following steps: 1) weighing the following components in parts by weight: 60 to 98 parts of coffee residue, 5 to 35 parts of activated carbon and 1 to 5 parts of edible powder essence or coffee essence; and 2) mixing the components obtained in the step 1) uniformly, packaging and storing. The air freshening bag prepared by the method effectively utilizes the coffee residues, improves the adsorption effect on formaldehyde by the air freshening bag and is favorable for air dehumidification.

Preparation method of dehumidifying and formaldehyde-removing coffee residue air freshening bag

The invention discloses a preparation method of a selenium nano double-emulsified micro-preparation with gastrointestinal tract slow release, nutritional supplement and cancer cell inhibition functions. The preparation method comprises the following steps of 1) preparing a W1 phase of a chitosan-selenium nano-preparation by using chitosan as a template; (2) adding the chitosan-selenium nano preparation W1 phase obtained in the step (1) into an O-phase container containing soybean oil-vitamin E, and carrying out high-pressure homogenization to form a primary emulsion of W1/O; and (3) adjustingthe pH value of the W1/O primary emulsion prepared in the step (2), and adding the W1/O primary emulsion into a W2 composite solution of a polysaccharide-whey protein stock solution to prepare the double emulsion. According to the method, a double-emulsification technology is adopted to prepare a double-emulsification oral delivery system with a core-shell structure. The selenium nano double-emulsified micro-preparation prepared by the method disclosed by the invention can effectively induce HepG2 apoptosis in vitro and inhibit the dosage of tumor growth in vivo.

Song Xiaoxiao

Papers

Effect of molecular weight of chitosan and its oligosaccharides on antitumor activities of chitosan-selenium nanoparticles.

Physicochemical stability and functional properties of selenium nanoparticles stabilized by chitosan, carrageenan, and gum Arabic.

Physicochemical and functional properties of chitosan-stabilized selenium nanoparticles under different processing treatments

Preparation method of dehumidifying and formaldehyde-removing coffee residue air freshening bag

Preparation method of selenium nano double-emulsified micro-preparation