Sophie Dix

TL;DR: The results showed that rats were sensitive to the changes made in all of the test conditions and that the level of discrimination varied within the 3 min test phase, and the first 2 min were found to be the most sensitive period.

TL;DR: Two tests designed specifically to distinguish performance of two putative divisions of recognition memory (the Remember/Know procedure and the use of receiver operating characteristics to distinguish familiarity and recollection), provide evidence for a selective sparing of the familiarity component of recognition.

TL;DR: Key strengths and weaknesses of each of the NMDAR hypofunction hypothesis approaches are described with regard to their ability to recapitulate the deficits seen in patients, and it is surprisingly difficult to identify any single aspect of cognitive function that possesses complete translational integrity.

TL;DR: Overall, the opportunity to induce a selective cognitive deficit in attention (5CSRT) or working memory (DMTP) in the rat is limited by both the NMDAR antagonist and the dose range used.

TL;DR: Despite nominally common mechanisms of action and often presumed biological equivalence, the NMDA antagonists tested produced very diverse effects on the expression of instrumental action, which implications with regard to animal modelling of schizophrenic psychotic symptoms are manifold.