Stefan Kahlert

TL;DR: It is demonstrated that ligand bound estrogen receptor α is required for rapid activation of the IGF-1R signaling cascade.

TL;DR: In this paper, the authors investigated whether cardiac myocytes and fibroblasts express functional estrogen receptors and found that treatment with E2 induced a significant increase in expression of the estrogen receptors α and β, progesterone receptor and connexin 43 in cardiac myocyte.

TL;DR: A novel observation of estrogen-induced downregulation of AT1 receptor expression could explain the association of estrogen deficiency with hypertension and atherosclerosis, because activation of the AT1 receptors plays a key role in the regulation of blood pressure, fluid homeostasis, and vascular cell growth.

TL;DR: Results show that E2 stimulates the expression of iNOS/eNOS in neonatal and adult cardiomyocytes in-vivo and in-Vitro, providing a potential mechanism of how estrogen may modulate NOS expression and NO formation in the myocardium.

TL;DR: It is shown that cyp450 aromatase is expressed in cardiac myocyte and incubation of cardiac myocytes with oestrogen precursors leads to sexual dimorphic transactivation of an oestrogens-responsive reporter plasmid, and this suggests that local Oestrogen biosynthesis of the heart is effective to activate ostrogen receptor alpha and beta, and downstream target genes in a gender-based fashion.