S
Stefanie Haasken
Researcher at Roy J. and Lucille A. Carver College of Medicine
Publications - 4
Citations - 597
Stefanie Haasken is an academic researcher from Roy J. and Lucille A. Carver College of Medicine. The author has contributed to research in topics: Inflammasome & Caspase 1. The author has an hindex of 4, co-authored 4 publications receiving 472 citations. Previous affiliations of Stefanie Haasken include University of Iowa.
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Journal ArticleDOI
Mechanism of NLRP3 inflammasome activation
TL;DR: The NLRP3 inflammasome is the most thoroughly studied of the inflammaome complexes that have been described thus far, perhaps owing to its disparate assortment of agonists.
Journal ArticleDOI
Immune complexes inhibit IL-1 secretion and inflammasome activation.
John R. Janczy,Ceren Ciraci,Stefanie Haasken,Yoichiro Iwakura,Alicia K. Olivier,Suzanne L. Cassel,Fayyaz S. Sutterwala +6 more
TL;DR: In vivo, administration of Ag in the form of an immune complex during priming of the immune response inhibited resultant adaptive immune responses in an NLRP3-dependent model of allergic airway disease, revealing an unexpected mechanism regulating CD4+ T cell differentiation.
Journal ArticleDOI
Immune Complexes Indirectly Suppress the Generation of Th17 Responses In Vivo.
Ceren Ciraci,Ceren Ciraci,John R. Janczy,Nidhi Jain,Stefanie Haasken,Cyntia Pecli e Silva,Cyntia Pecli e Silva,Claudia F. Benjamim,Jeffrey J. Sadler,Alicia K. Olivier,Yoichiro Iwakura,Dmitry M. Shayakhmetov,Fayyaz S. Sutterwala,Suzanne L. Cassel +13 more
TL;DR: It is shown that modification of that immunization with CFA to include IgG-Ova immune complexes results in the suppression of CFA-induced Th17 responses and a concurrent enhancement of Ova-specific Th2 responses, and the mechanism by which these immune complexes suppress Th 17 responses is through the enhancement of IL-10 production.
Journal ArticleDOI
Damage control: Management of cellular stress by the NLRP3 inflammasome
TL;DR: It is shown that the NLRP3 inflammasome contributes to oxidative DNA damage and modulates a number of pathways involved in DNA damage repair, cell cycle, and apoptosis, suggesting a novel role for the NL RP3 infammasome inDNA damage responses following cellular stress.