S
Stella Kourembanas
Researcher at Boston Children's Hospital
Publications - 114
Citations - 12554
Stella Kourembanas is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Pulmonary hypertension & Hypoxia (medical). The author has an hindex of 47, co-authored 107 publications receiving 11315 citations. Previous affiliations of Stella Kourembanas include Children's Medical Center of Dallas & Boston Medical Center.
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Journal ArticleDOI
Hypoxia Regulates Vascular Endothelial Growth Factor Gene Expression in Endothelial Cells Identification of a 5′ Enhancer
TL;DR: Using a DNA fragment containing human VEGF promoter sequence, a 28-bp element is identified that is necessary and sufficient to upregulate transcription in response to hypoxia and may be the binding site for certain constitutive binding proteins.
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Smooth muscle cell-derived carbon monoxide is a regulator of vascular cgmp
TL;DR: It is reported here that smooth muscle cells produce CO via HO and that it regulates cGMP levels in these cells, and that its product, CO, may regulate vascular tone under physiologic and pathophysiologic conditions.
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Hypoxia induces endothelin gene expression and secretion in cultured human endothelium.
TL;DR: A role for endothelin is suggested in the control of regional blood flow in the vasculature in response to changes in oxygen tension, as well as a number of other growth-factor-encoding genes, including transforming growth factor-beta.
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Exosomes Mediate the Cytoprotective Action of Mesenchymal Stromal Cells on Hypoxia-Induced Pulmonary Hypertension
Changjin Lee,S. Alex Mitsialis,Muhammad Aslam,Sally H. Vitali,Eleni Vergadi,Georgios Konstantinou,Konstantinos Sdrimas,Angeles Fernandez-Gonzalez,Stella Kourembanas +8 more
TL;DR: This study indicates that MEX exert a pleiotropic protective effect on the lung and inhibit pulmonary hypertension through suppression of hyperproliferative pathways, including STAT3-mediated signaling induced by hypoxia.
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Exosomes: Vehicles of Intercellular Signaling, Biomarkers, and Vectors of Cell Therapy
TL;DR: The biogenesis of exosomes, their molecular composition, and their role as messengers of intercellular communication are reviewed, focusing on their potential as therapeutic vectors for stem cell therapy.