Showing papers by "Stephen Attwood published in 1997"
01 Jan 1997
TL;DR: Comparison with Other Species The adenocarcinomas induced under the above mentioned experimental conditions are morpho logically similar to their human counterpart (Webb and Busattil 1978; Gassner 1988); from a comparative standpoint, it seems interesting that the experimental adenOCarcinoma were induced only after chronic reflux esophagitis plus subse quent exposure to the carcinogen.
Abstract: Comparison with Other Species The adenocarcinomas induced under the above mentioned experimental conditions are morpho logically similar to their human counterpart (Webb and Busattil 1978; Gassner 1988). From a comparative standpoint, it seems interesting that the experimental adenocarcinomas were induced only after chronic reflux esophagitis plus subse quent exposure to the carcinogen and that in hu mans most of the adenocarcinomas of the distal third of the esophagus are associated with longstanding reflux esophagitis, which produces glandular metaplasia (Barrett's esophagus) (Pera et al. 1993b). In humans, the risk of developing glandular metaplasia has been estimated to be between 2 % and 11 % in patients with reflux esophagitis (Thompson et al. 1983). Numerous authors have noted a strong correlation between the presence of glandular metaplasia and the development of adenocarcinoma of the distal esophagus in humans (Pera et al. 1993b,c; Thompson et al. 1983; Winters et al. 1987).