S
Stephen C. Winans
Researcher at Cornell University
Publications - 125
Citations - 14482
Stephen C. Winans is an academic researcher from Cornell University. The author has contributed to research in topics: Agrobacterium tumefaciens & Ti plasmid. The author has an hindex of 53, co-authored 124 publications receiving 13910 citations. Previous affiliations of Stephen C. Winans include University of Washington & Trinity University.
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Journal ArticleDOI
Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators.
TL;DR: How the marine luminescent bacterium V. fischeri uses the LuxR and LuxI proteins for intercellular communication is reviewed and a newly discovered family of LuxRand LuxI homologs in diverse bacterial species is described.
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Census and consensus in bacterial ecosystems: the LuxR-LuxI family of quorum-sensing transcriptional regulators.
TL;DR: Genetic analyses of particular bacterial genes, operons, or regulons that are expressed preferentially at high cell densities have revealed a high degree of functional conservation, while also uncovering features that are unique to each.
Journal ArticleDOI
A LuxR-LuxI type regulatory system activates Agrobacterium Ti plasmid conjugal transfer in the presence of a plant tumor metabolite.
W C Fuqua,Stephen C. Winans +1 more
TL;DR: TraR-AAI-mediated activation in wild-type Agrobacterium strains was dramatically enhanced by culturing on solid media, suggesting a possible role in cell density sensing.
Journal ArticleDOI
Structure of a bacterial quorum-sensing transcription factor complexed with pheromone and DNA
Rongguang Zhang,Terina Pappas,Jennifer L. Brace,Paula C. Miller,Paula C. Miller,Tim N. Oulmassov,John M. Molyneaux,John M. Molyneaux,John C. Anderson,James K. Bashkin,James K. Bashkin,Stephen C. Winans,Andrzej Joachimiak +12 more
TL;DR: TraR of Agrobacterium tumefaciens was solved as a complex with the pheromone N-3-oxooctanoyl-l-homoserine lactone and its TraR DNA-binding site and the structure of a LuxR-type protein is presented.
Journal ArticleDOI
Enzymatic Synthesis of a Quorum-Sensing Autoinducer Through Use of Defined Substrates
Margret I. Moré,L. David Finger,Joel L. Stryker,Clay Fuqua,Anatol Eberhard,Stephen C. Winans +5 more
TL;DR: Results demonstrate the enzymatic synthesis of an autoinducer through the use of purified substrates.