The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Secreted and Transmembrane Polypeptides and Nucleic Acids Encoding the Same

A system for producing cast components from molten metal. One form of the present invention includes a system for the precision pouring of molten metal within a casting mold. The precision pouring system is driven by a pressure differential.

Method and apparatus for production of a cast component

An affiliation manager provides each of typically hundreds of users with a calendar of appointments and a task list each including icons for capturing time and expenses accrued by the user when attending a particular appointment or performing a particular task. A subset of collected captured time and expenses may be transferred to each requesting client for use by independent accounting systems. Management of appointments and tasks from a central database promotes collaboration among users, simplifies sharing of schedule information among users, and provides context for data entry. Each user may create any number of affiliations, each affiliation describing affiliations of the user in numerous projects, organizations, employments, and activities. Each user may admit other users to share his or her affiliations, thereby promoting collaboration of many users for jointly attending meetings and jointly performing tasks. Context permits automatic intuitive association of email, chat messages, notes, and documents to records for persons, locations, resources, appointments, tasks, and projects for integrated affiliation management services. Requests for queries and forms are interpreted according to the context in which the user issued the request. Requests are made via a common set of icons and links on each item of a list provided by a prior query.

Systems and methods for managing affiliations

A wide gap braze repair, particularly for a gas turbine engine vane or a component in the hot section of the engine. The repair is characterized by a braze filled void in a damaged area of the component, a laser shock peened surface over the repaired area of the braze filled void, and a region of deep compressive residual stresses imparted by laser shock peening (LSP) extending from the laser shock peened surface into the repair.

Laser shock peening for gas turbine engine vane repair

This invention provides methods of treatment for work products of materials such as steel, bronze, plastic, etc. and particularly welded steel bodies by pulse impact energy, preferably ultrasonic, to relax fatigue and aging and extend expectant life. The treatment may occur (a) at original production, (b) during the active life period for maintenance or (c) after failure in a repair stage. The ultrasonic treatment improves the work product strength. In welded products residual stress patterns near the weld sites are relaxed and micro-stress defects such as voids and unusual grain boundaries are reduced. The basic method steps are non-destructive in nature, inducing interior pulse compression waves with ultrasonic transducers and accessory tools impacting an external product surface with enough impulse energy to heat and temporarily plasticize the metal interior and relax stresses. The nature of the work product interior structure being treated is determined by sensing the mechanical movement at the impact surface of the work body to produce feedback frequency and phase signals responsive to input impact signals. These signals automatically conform driving pulse energy frequency and phase to the input transducers to match the mechanical resonance frequency of the working transducers and increase efficiency of energy transfer. Such feedback signals also are available for automated procedures which can improve product quality and consistency.

Ultrasonic impact methods for treatment of welded structures

A series of braze materials for brazing superalloy substrates at effective brazing temperatures above about 2300° F. is described. The braze materials are formulated as mixtures of cobalt- and nickel-base alloy powders. Each such braze material contains at least two components, one of which is predominantly liquid at the effective brazing temperature, and one of which remains substantially solid at that temperature. The brazing materials solidify by an isothermal solidification process. Unless otherwise limited by the temperature capability of the superalloy substrate being joined, these brazing alloys provide joints that have useful strength at temperatures significantly higher than joints made with prior art brazing alloys.

Alloy powder mixture for brazing of superalloy articles

An improved mixture of alloy powders is provided for use in treating a preselected article alloy, for example, to repair or join multiple components of the article. The mixture has at least three distinct groups of alloy powders which together define a mixture composition range, with each alloy powder of the groups characterized by a composition and melting range different from the others and from the article alloy. In a preferred form, the mixture composition range comprises, by weight, 15-30% Cr, 1.5-6% W, 0.4-4% Al, 1-11% Ti, 1-6% Ta, up to 1.5% B, up to 0.5% Si, up to 0.2% Zr, up to 3% Mo, up to 0.3% Hf, up to 6% Cb, up to 2% Re, with the balance selected from Co and Ni along with incidental impurities.

Alloy powder mixture for treating alloys

A superalloy article is fabricated by casting a high melting temperature superalloy composition and then refurbishing the primary defects that are found in the surface of the cast piece. The article is refurbished by excising the primary defects and a surrounding portion of metal by grinding, filling the excised volume with metal of the same composition as the cast article by welding or a similar technique, smoothing the surface around any resulting filler metal defects, and applying a cladding powder to the surface from which the filler metal defects are removed. The cladding powder is applied by painting a binder onto the surface and then dusting cladding powder onto the binder before it has dried. The cladding powder is a mixture of particles of a high melting temperature superalloy and particles of a lower melting temperature metal. The article is heated to a preselected temperature, depending on the alloy, to melt and subsequently solidify the cladding powder. Finally, the article is hot isostatically pressed to achieve final closure of surface defects.

Fabrication of cast articles from high melting temperature superalloy compositions

A braze material is provided for repairing an article, and particularly components formed from cobalt and nickel-base superalloys, such as gas turbine engine components. The braze material is composed of high melt particles distributed within a braze alloy. The braze alloy can be any suitable bonding material of the type used to repair components that must operate at high temperatures. The particles are single crystal, directionally solidified or equiaxed particles formed from a superalloy or ceramic material, or mixtures thereof. Importantly, the particles have an aspect ratio (length to width) of at least 4:1. The braze material can be provided and used in the form of a slurry, a presintered preform, a plasticized tape, or in a powdered form.

Stephen Joseph Ferrigno

Papers

Laser shock peening for gas turbine engine vane repair

Alloy powder mixture for brazing of superalloy articles

Alloy powder mixture for treating alloys

Fabrication of cast articles from high melting temperature superalloy compositions

High temperature braze material