S
Steven A. Kawamoto
Researcher at University of Michigan
Publications - 3
Citations - 297
Steven A. Kawamoto is an academic researcher from University of Michigan. The author has contributed to research in topics: Surface plasmon resonance & Wnt signaling pathway. The author has an hindex of 3, co-authored 3 publications receiving 269 citations.
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Journal ArticleDOI
Design of Triazole-Stapled BCL9 α-Helical Peptides to Target the β-Catenin/B-Cell CLL/lymphoma 9 (BCL9) Protein–Protein Interaction
TL;DR: The use of the Huisgen 1,3-dipolar cycloaddition reaction to generate triazole-stapled BCL9 α-helical peptides is reported, which show a marked increase in helical character and an improvement in binding affinity and metabolic stability relative to wild-type and linear BCL 9 peptides.
Journal ArticleDOI
Design and characterization of bivalent Smac-based peptides as antagonists of XIAP and development and validation of a fluorescence polarization assay for XIAP containing both BIR2 and BIR3 domains.
Zaneta Nikolovska-Coleska,Jennifer L. Meagher,Sheng Jiang,Steven A. Kawamoto,Wei Gao,Han Yi,Dongguang Qin,Peter P. Roller,Jeanne A. Stuckey,Shaomeng Wang +9 more
TL;DR: The designed bivalent Smac-based peptides mimic the mode of dimeric Smac protein in their interaction with XIAP containing both BIR2 and BIR3 domains and achieve extremely high potency in binding and functional assays.
Journal ArticleDOI
Analysis of the Interaction of BCL9 with β-Catenin and Development of Fluorescence Polarization and Surface Plasmon Resonance Binding Assays for this Interaction
Steven A. Kawamoto,Andrea D. Thompson,Adriana Coleska,Zaneta Nikolovska-Coleska,Han Yi,Shaomeng Wang +5 more
TL;DR: These studies provide not only further insight into the interaction between BCL9 and beta-catenin but also quantitative and reliable biochemical binding assays for the discovery of potent and specific small-molecule inhibitors of this interaction.