There is considerable pressure to define the key requirements of 5G, develop 5G standards, and perform technology trials as quickly as possible. Normally, these activities are best done in series but there is a desire to complete these tasks in parallel so that commercial deployments of 5G can begin by 2020. 5G will not be an incremental improvement over its predecessors; it aims to be a revolutionary leap forward in terms of data rates, latency, massive connectivity, network reliability, and energy efficiency. These capabilities are targeted at realizing high-speed connectivity, the Internet of Things, augmented virtual reality, the tactile internet, and so on. The requirements of 5G are expected to be met by new spectrum in the microwave bands (3.3-4.2 GHz), and utilizing large bandwidths available in mm-wave bands, increasing spatial degrees of freedom via large antenna arrays and 3-D MIMO, network densification, and new waveforms that provide scalability and flexibility to meet the varying demands of 5G services. Unlike the one size fits all 4G core networks, the 5G core network must be flexible and adaptable and is expected to simultaneously provide optimized support for the diverse 5G use case categories. In this paper, we provide an overview of 5G research, standardization trials, and deployment challenges. Due to the enormous scope of 5G systems, it is necessary to provide some direction in a tutorial article, and in this overview, the focus is largely user centric, rather than device centric. In addition to surveying the state of play in the area, we identify leading technologies, evaluating their strengths and weaknesses, and outline the key challenges ahead, with research test beds delivering promising performance but pre-commercial trials lagging behind the desired 5G targets.

5G : A tutorial overview of standards, trials, challenges, deployment, and practice

Revisions to the staging and classification of mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC).

This paper presents the design and implementation of SpotFi, an accurate indoor localization system that can be deployed on commodity WiFi infrastructure. SpotFi only uses information that is already exposed by WiFi chips and does not require any hardware or firmware changes, yet achieves the same accuracy as state-of-the-art localization systems. SpotFi makes two key technical contributions. First, SpotFi incorporates super-resolution algorithms that can accurately compute the angle of arrival (AoA) of multipath components even when the access point (AP) has only three antennas. Second, it incorporates novel filtering and estimation techniques to identify AoA of direct path between the localization target and AP by assigning values for each path depending on how likely the particular path is the direct path. Our experiments in a multipath rich indoor environment show that SpotFi achieves a median accuracy of 40 cm and is robust to indoor hindrances such as obstacles and multipath.

https://dl.acm.org/doi/pdf/10.1145/2785956.2787487

SpotFi: Decimeter Level Localization Using WiFi

Some pioneer WiFi signal based human activity recognition systems have been proposed. Their key limitation lies in the lack of a model that can quantitatively correlate CSI dynamics and human activities. In this paper, we propose CARM, a CSI based human Activity Recognition and Monitoring system. CARM has two theoretical underpinnings: a CSI-speed model, which quantifies the correlation between CSI value dynamics and human movement speeds, and a CSI-activity model, which quantifies the correlation between the movement speeds of different human body parts and a specific human activity. By these two models, we quantitatively build the correlation between CSI value dynamics and a specific human activity. CARM uses this correlation as the profiling mechanism and recognizes a given activity by matching it to the best-fit profile. We implemented CARM using commercial WiFi devices and evaluated it in several different environments. Our results show that CARM achieves an average accuracy of greater than 96%.

/pdf/understanding-and-modeling-of-wifi-signal-based-human-s17lmln5eh.pdf

Understanding and Modeling of WiFi Signal Based Human Activity Recognition

Psoriasis is a common, chronic, inflammatory, multisystem disease with predominantly skin and joint manifestations affecting approximately 2% of the population. In this second of 5 sections of the guidelines of care for psoriasis, we give an overview of psoriatic arthritis including its cardinal clinical features, pathogenesis, prognosis, classification, assessment tools used to evaluate psoriatic arthritis, and the approach to treatment. Although patients with mild to moderate psoriatic arthritis may be treated with nonsteroidal anti-inflammatory drugs and/or intra-articular steroid injections, the use of disease-modifying antirheumatic drugs, particularly methotrexate, along with the biologic agents, are considered the standard of care in patients with more significant psoriatic arthritis. We will discuss the use of disease-modifying antirheumatic drugs and the biologic therapies in the treatment of patients with moderate to severe psoriatic arthritis.

https://www.jaad.org/article/S0190-9622(09)00012-7/pdf

Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 2. Psoriatic arthritis: Overview and guidelines of care for treatment with an emphasis on the biologics

Self-interference cancellation invalidates a long-held fundamental assumption in wireless network design that radios can only operate in half duplex mode on the same channel. Beyond enabling true in-band full duplex, which effectively doubles spectral efficiency, self-interference cancellation tremendously simplifies spectrum management. Not only does it render entire ecosystems like TD-LTE obsolete, it enables future networks to leverage fragmented spectrum, a pressing global issue that will continue to worsen in 5G networks. Self-interference cancellation offers the potential to complement and sustain the evolution of 5G technologies toward denser heterogeneous networks and can be utilized in wireless communication systems in multiple ways, including increased link capacity, spectrum virtualization, any-division duplexing (ADD), novel relay solutions, and enhanced interference coordination. By virtue of its fundamental nature, self-interference cancellation will have a tremendous impact on 5G networks and beyond.

Applications of self-interference cancellation in 5G and beyond

This paper presents PinPoint, a technique for localizing rogue interfering radios that adhere to standard protocols in the inhospitable ISM band without any cooperation from the interfering radio. PinPoint is designed to be incrementally deployed on top of existing 802.11 WLAN infrastructure, and used by network administrators to identify and troubleshoot sources of interference which may be disrupting the network. PinPoint's key contribution is a novel algorithm that accurately computes the line of sight angle of arrival (AoA) and cyclic signal strength indicator (CSSI) of the target interfering signal at all APs, even when the line of sight (LoS) component is buried by stronger multipath components, interference and noise. PinPoint leverages this algorithm to design an optimization technique, which can localize interfering radios and simultaneously identify the type of interference. Unlike several localization techniques which require extensive pre-deployment calibration (e.g. RF-Fingerprinting), PinPoint requires very little calibration by the network administrator, and uses a novel algorithm to self-initialize its bearings, even if the locations of some AP are initially unknown and are oriented randomly. We implement PinPoint on WARP software radios and deploy in an indoor testbed spanning an entire floor of our department. We compare PinPoint with the best known prior RSSI [8, 11] and MUSIC-AoA based approaches and show that PinPoint achieves a median localization error of 0.97 meters, which is around three times lower compared to the RSSI [8, 11] and MUSIC-AoA based approaches.

/pdf/pinpoint-localizing-interfering-radios-14bu7p2cxt.pdf

PinPoint: localizing interfering radios

Deficiencies of Leu-8 and CD7 antigens are exhibited by CD3+ T cells in the skin lesions of most patients with mycosis fungoides/Sezary syndrome. To determine whether these antigenic abnormalities are limited to involved skin, we studied Leu-8/CD7 expression in 21 skin lesions of mycosis fungoides/Sezary syndrome obtained from 16 patients and compared them with their peripheral blood leukocytes obtained concurrently. There was no correlation between Leu-8/CD7 values in skin lesions versus blood. Blood values were relatively uniform; most patients had 50% or greater of CD3+, Leu-8+ T cells and CD3+, CD7+ T cells. In contrast, skin values were highly heterogeneous; most patients lacked expression of Leu-8 or CD7 by the majority of lesional CD3+ T cells. Furthermore, Leu-8/CD7 antigen deficiency was present in lesional skin in one patient with mycosis fungoides but not in her concurrently sampled pityriasis lichenoides chronica or blood. These findings suggest that Leu-8/CD7 antigen deficiencies in skin lesions of mycosis fungoides/Sezary syndrome do not represent generalized antigenic abnormalities of CD3+ T cells in other body compartments and that within the skin, these deficiencies are disease specific within individual patients with more than one dermatosis. Comparative peripheral blood immunophenotyping of the patients with mycosis fungoides/Sezary syndrome and of the control subjects indicated that the control ranges of CD3+/Leu-8+ and CD3+/CD7+ T cells (33% or greater) extend lower than reported previously (60% or greater) and suggested that leukemic involvement in patients with mycosis fungoides/Sezary syndrome may correlate with percentages of CD3+, Leu8+ and/or CD3+, CD7+ T cells that fall below the revised control range.

Leu-8/CD7 antigen expression by CD3+ T cells: Comparative analysis of skin and blood in mycosis fungoides/Sézary syndrome relative to normal blood values

Background: A new class of topical receptor-selective acetylenic retinoids, the first of which is tazarotene, has been developed. Objective: Our purpose was to compare the safety, efficacy, and duration of therapeutic effect of 12 weeks of once-daily tazarotene 0.1% and 0.05% gel with that of twice-daily fluocinonide 0.05% cream in the treatment of patients with plaque psoriasis. Methods: Three hundred forty-eight patients with plaque psoriasis were enrolled and 275 patients completed a multicenter, investigator-masked, randomized, parallel-group clinical trial. Results: Both tazarotene gels were as effective as fluocinonide in reducing plaque elevation after 1 week of treatment, and tazarotene 0.1% gel was similar to fluocinonide in reducing scaling of trunk/limb lesions at all study weeks except week 4. Tazarotene 0.1% gel was similar to fluocinonide in reducing scaling of knee/elbow lesions at weeks 8 and 12. Fluocinonide had a significantly greater effect on erythema than tazarotene at weeks 2 through 8. However, treatments were not significantly different at week 12, and tazarotene demonstrated significantly better maintenance of therapeutic effect after cessation of therapy. Conclusion: Tazarotene 0.1% and 0.05% gels were safe and effective in the treatment of mild-to-moderate plaque psoriasis.(J Am Acad Dermatol 1998;38:705-11.)

Once-daily tazarotene gel versus twice-daily fluocinonide cream in the treatment of plaque psoriasis

A circuit that cancels a self-interference signal includes, in part, a pair of signal paths that are substantially in phase, each of which paths includes a passive coupler, a delay element and a variable attenuator. The circuit further includes, in part, a first group of P signal paths each of which is substantially in phase with the pair of paths, and a second group of M signal paths each of which is substantially out-of-phase relative to the pair of signal paths. Each of the P and M signal paths includes a delay element and a variable attenuator. Furthermore, (P−1) signal paths of the first group of P signal paths, and (M−1) signal paths of the second group of M signal paths include a passive coupler. Optionally, each of the M signal paths is optionally 180° out-of-phase relative to the pair of signal paths.

Steven Hong

Papers

Applications of self-interference cancellation in 5G and beyond

PinPoint: localizing interfering radios

Leu-8/CD7 antigen expression by CD3+ T cells: Comparative analysis of skin and blood in mycosis fungoides/Sézary syndrome relative to normal blood values

Once-daily tazarotene gel versus twice-daily fluocinonide cream in the treatment of plaque psoriasis

Feed forward signal cancellation