S
Sudhir Agrawal
Researcher at University of Massachusetts Medical School
Publications - 404
Citations - 22597
Sudhir Agrawal is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Oligonucleotide & CpG site. The author has an hindex of 80, co-authored 402 publications receiving 22211 citations. Previous affiliations of Sudhir Agrawal include Vassar College & Fortune.
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Journal ArticleDOI
Detection of nucleic acid hybridization by nonradiative fluorescence resonance energy transfer
TL;DR: The results establish that fluorescence modulation and nonradiative fluorescence resonance energy transfer can detect nucleic acid hybridization in solution and these techniques, with further development, may also prove useful for detecting and quantifying nucleic acids Hybridization in living cells.
PatentDOI
Site-specific functionalization of oligodeoxynucleotides for non-radioactive labelling
Sudhir Agrawal,Jin-Yan Tang +1 more
TL;DR: These compounds are compounds consisting of a plurality of nucleosides which are covalently linked by at least one aminoalkylphosphoramidate linkage of the formula ##STR1## wherein n=2 to 6 and Nu1 and Nu2 represent nucleoside phosphates.
Journal ArticleDOI
Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice
TL;DR: The surprising observation was made that chain length extension of administered [S]oligonucleotide occurred in kidney, liver, and intestine, which provides an initial definition of parameters for the pharmaceutical development of antisense oligonucleotides.
Journal ArticleDOI
Antisense oligonucleotides: towards clinical trials
TL;DR: The experience gained is providing a basis for designing a second generation of antisense oligonucleotides, which have the ability to selectively block disease-causing genes and inhibiting production of disease-associated proteins.
Patent
Hybrid oligonucleotide phosphorothioates
Valeri Metelev,Sudhir Agrawal +1 more
TL;DR: In this article, the authors provided hybrid oligonucleotides having phosphorothioate or phosphorodithioate internucleotide linkages, and both deoxyribonucleosides and ribon nucleosides or 2′-substituted ribonosides with superior properties of duplex formation with RNA, nuclease resistance, and RNase H activation.