S
Suju P. Mathew
Researcher at Imperial College London
Publications - 10
Citations - 886
Suju P. Mathew is an academic researcher from Imperial College London. The author has contributed to research in topics: Enantioselective synthesis & Catalysis. The author has an hindex of 9, co-authored 10 publications receiving 861 citations. Previous affiliations of Suju P. Mathew include University of Manchester.
Papers
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Journal ArticleDOI
Thermodynamic control of asymmetric amplification in amino acid catalysis
Martin Klussmann,Hiroshi Iwamura,Hiroshi Iwamura,Suju P. Mathew,David H. Wells,David H. Wells,Urvish Pandya,Alan Armstrong,Donna G. Blackmond +8 more
TL;DR: This work shows an alternative mechanism that gives rise to asymmetric amplification based on the equilibrium solid-liquid phase behaviour of amino acids in solution, which is robust and can operate in aqueous systems, making it an appealing proposition for explaining one of the most tantalizing examples of asymmetric amplified.
Journal ArticleDOI
Amplification of Enantiomeric Excess in a Proline-Mediated Reaction†
Journal ArticleDOI
In situ catalyst improvement in the proline-mediated alpha-amination of aldehydes.
TL;DR: Kinetic investigations show that the proline-mediated α-amination of aldehydes exhibits autoinductive rate behavior and amplification of product enantiomeric excess, which implicate amino acid catalysis in rationalizations of the origin of biological homochirality.
Journal ArticleDOI
Probing the active catalyst in product-accelerated proline-mediated reactions.
Hiroshi Iwamura,David H. Wells,Suju P. Mathew,Martin Klussmann,and Alan Armstrong,Donna G. Blackmond +5 more
TL;DR: A new catalytic cycle involving only soluble proline complexes or adducts is proposed for the reactions in eq 1 based on kinetic observations and molecular modeling studies to rationalize the observations of accelerating reaction rate in both the alpha-aminooxylation and alpha-amination reactions.